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The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease

被引：252
作者：
Pablo Engel
Michael J. Eck
Cox Terhorst
机构：
[1] Dept. of Cell. Biology and Pathology, Medical School, University of Barcelona
来源：
Nature Reviews Immunology | 2003年 / 3卷 / 10期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nri1202
中图分类号：
学科分类号：
摘要：
SAP (signalling lymphocytic activation molecule (SLAM)-associated protein) is a T- and natural killer (NK)-cell-specific protein containing a single SH2 domain encoded by a gene that is defective or absent in patients with X-linked lymphoproliferative syndrome (XLP). The SH2 domain of SAP binds with high affinity to the cytoplasmic tail of the haematopoietic cell-surface glycoprotein SLAM and five related receptors. SAP regulates signal transduction of the SLAM-family receptors by recruiting SRC kinases. Similarly, the SAP-related proteins EAT2A and EAT2B are thought to control signal transduction that is initiated by SLAM-related receptors in professional antigen-presenting cells. In this review, we discuss recent findings on the structure and function of proteins of the SAP and SLAM families.
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页码：813 / 821
页数：8
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