Neurobiology and the Drosophila genome

被引：25

作者：

Yoshihara M. ^{[1
]}

Ensminger A.W. ^{[1
]}

Littleton J.T. ^{[1
]}

机构：

[1] Center for Learning and Memory, Department of Biology, Massachusetts Inst. of Technology, Cambridge, MA 02139

来源：

Functional & Integrative Genomics | 2001年 / 1卷 / 4期

关键词：

Axonal pathfinding; Ion channels; Neurotransmitter release; Synapse;

D O I：

10.1007/s101420000029

中图分类号：

学科分类号：

摘要：

The sequencing and annotation of the euchromatin of the Drosophila melanogaster genome provides an important foundation that allows neurobiologists to work back from the complete gene set of neuronal proteins to an eventual understanding of how they function to produce cognition and behavior. Here we provide a brief survey of some of the key insights that have emerged from analyzing the complete gene set in Drosophila. Not surprisingly, both the Caenorhabditis elegans and Drosophila genomes contain a conserved repertoire of neuronal signaling proteins that are also present in mammals. This includes a large number of neuronal cell adhesion receptors, synapse-organizing proteins, ion channels and neurotransmitter receptors, and synaptic vesicle-trafficking proteins. In addition, there are a significant number of fly homologs of human neurological disease loci, suggesting that Drosophila is likely to be an important disease model for human neuropathology in the near future. The experimental analysis of the Drosophila neuronal gene set will provide important in-sights into how the nervous system functions at the cellular level, allowing the field to integrate this information into the framework of ultimately understanding how neuronal ensembles mediate cognition and behavior.

引用

页码：235 / 240

页数：5

共 31 条

[1] Adams M.D., Et al., The genome sequence of Drosophila melanogaster, Science, 287, pp. 2185-2195, (2000)
[2] Benzer S., Behavioral mutants of Drosophila isolated by countercurrent distribution, Proc Natl Acad Sci USA, 58, pp. 1112-1119, (1967)
[3] Broadie K.S., Bate M., Development of the embryonic neuromuscular synapse of Drosophila melanogaster, J Neurosci, 13, pp. 144-166, (1993)
[4] Brody T., Cravchik A., Drosophila melanogaster G protein-coupled receptors, J Cell Biol, 150, (2000)
[5] Desai C.J., Garrity P.A., Keshishian H., Zipursky S.L., Zinn K., The Drosophila SH2-SH3 adapter protein Dock is expressed in embryonic axons and facilitates synapse formation by the RP3 motoneuron, Development, 126, pp. 1527-1535, (1999)
[6] Feany M.B., Bender W.W., A Drosophila model of Parkinson's disease, Nature, 404, pp. 394-398, (2000)
[7] Fortini M.E., Skupski M.P., Boguski M.S., Hariharan I.K., A survey of human disease gene counterparts in the Drosophila genome, J Cell Biol, 150, (2000)
[8] Garrity P.A., Rao Y., Salecker I., McGlade J., Pawson T., Zipursky S.L., Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein, Cell, 85, pp. 639-650, (1996)
[9] Hynes R.O., Zhao Q., The evolution of cell adhesion, J Cell Biol, 150, (2000)
[10] Ikeda K., Ozawa S., Hagiwara S., Synaptic transmission reversibly conditioned by single-gene mutation in Drosophila melanogaster, Nature, 259, pp. 489-491, (1976)

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