Peroxisome proliferator-activated receptors.

被引：47

作者：

Ziouzenkova O. ^{[1
]}

Perrey S. ^{[1
]}

Marx N. ^{[1
]}

Bacqueville D. ^{[1
]}

Plutzky J. ^{[1
]}

机构：

[1] Division of Cardiovascular Medicine, Brigham and Women's Hospital, LMRC 307, 221 Longwood Avenue, Boston, 02115, MA

来源：

Current Atherosclerosis Reports | 2002年 / 4卷 / 1期

关键词：

Troglitazone; Arterioscler Thromb Vasc Biol; PPAR Agonist; PPAR Activator; PPAR Ligand;

D O I：

10.1007/s11883-002-0063-x

中图分类号：

学科分类号：

摘要：

An exciting and rapidly evolving area in vascular biology and atherosclerosis research over the past 3 years has been the establishment of peroxisome proliferator-activated receptor (PPAR) expression in the vascular and inflammatory cells, and the emerging picture of the roles these ligand-activated nuclear receptor/transcription factors might play in vascular biology and atherosclerosis. Such work is all the more compelling given the ongoing clinical use of PPAR activators in patients. Thiazolidinediones (PPAR-g agonists) are used as insulin sensitizers in diabetic patients known to be at extraordinarily high risk for cardiovascular disease, whereas fibrates (PPAR-a agonists) are used to treat dyslipidemia, particularly in the case of high triglycerides and low high-density lipoprotein cholesterol.

引用

页码：59 / 64

页数：5

共 149 条

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