Effect of moxibustion on IL-1β and IL-2 in rat models of rheumatoid arthritis

被引：23

作者：

Hu L. ^{[1
]}

Lars D.-H. ^{[1
]}

Song X.-G. ^{[1
]}

Tang Z.-L. ^{[1
]}

Cai R.-L. ^{[1
]}

He L. ^{[1
]}

Luo L. ^{[1
]}

机构：

[1] Research Institute of Acupuncture and Meridian, Anhui College of Traditional Chinese Medicine

来源：

Journal of Acupuncture and Tuina Science | 2010年 / 8卷 / 3期

关键词：

Arthritis; Interleukin-1; beta; Interleukin-2; Moxibustion Therapy; Rats; Rheumatoid;

D O I：

10.1007/s11726-010-0394-z

中图分类号：

学科分类号：

摘要：

Objective: To observe the influence on IL-1β and IL-2 in rat models with rheumatoid arthritis after moxibustion on Shenshu (BL 23) and Zusanli (ST 36) points, and to discuss the mechanism of moxibustion. Methods: Fifty male Wistar rats were divided randomly into 5 groups, control group, model group, drug group, moxibustion group, and laser group, 10 for each. Four groups except the normal group were built on the model of rheumatoid arthritis. The changes of body weight and plantar circumference were measured and the level of IL-1β, IL-2 in sera were examined by ELISA. Results: Compared with the model group, the weight and plantar circumference of rats in the moxibustion group were improved significantly after treatment (P<0.01), and the improvement of plantar circumference also had significant differences compared with the drug group and the laser group (P<0.05). The level of IL-1β, IL-2 in sera were down regulated in the moxibustion group and the laser group, which had statistical differences compared with the model group (P<0.05), but no statistical differences were found when comparing with the drug group. Conclusion: Moxibustion obviously improves the toe tumefaction of the rats with rheumatoid arthritis, which is better than CO2 laser of 10.6 μm. On the aspect of decreasing the amount of IL-1β, IL-2, CO2 laser of 10.6 μm is similar with moxibustion. © 2010 Shanghai Research Institute of Acupuncture and Meridian and Springer-Verlag Berlin Heidelberg.

引用

页码：149 / 153

页数：4

共 18 条

[1]

Tang Z.-L., Song X.-G., Zhang F.-Q., Et al., Study on the Action Mechanism of Moxibustion in Anti-inflammation and Immunoregulation in Rheumatoid Arthritis Rats, Acupuncture Research, 28, 4, pp. 292-298, (2003)

[2]

Cai R.-L., Hu L., Song X.-G., Et al., Summary of Clinical and Experimental Research on the Moxibustion Treatment of Arthritis, Clinial Journal of Traditional Chinese Medicine, 20, 4, pp. 427-429, (2008)

[3]

Xiao C.-H., Gu W.-W., Li L.-Y., Et al., Pathology Research on the Animal Model of Anemofrigiddamp and Anemopyretic-damp of Rheumatoid Arthritis, Acta Laboratorium Animalis Scientia Sinica, 6, 1, pp. 6-11, (1998)

[4]

Zhou H.-Y., Wei Z., Liu X.-G., On RA Experimental Model Integrates Disease and Syndrome, Chinese Archives of Traditional Chinese Medicine, 25, 8, pp. 1745-1746, (2007)

[5]

Wood D.D., Ihrie E.J., Hamerman D., Release of Interleukin-1 from Human Synovium Tissue in Vitro, Arthritis Rheum, 28, 8, pp. 853-862, (1985)

[6]

Strand V., Kavanaugh A.F., The Role of Interleukin-1 in Bone Resorption in Rheumatoid Arthritis, Rheumatology, 43, SUPPL. 3, (2004)

[7]

Zwerina J., Hayer S., Tohidast-Akrad M., Et al., Single and Combined Inhibition of Tumor Necrosis Factor, Interleukin-1, and RANKL Pathways in Tumor Necrosis Factor-induced Arthritis: Effects on Synovium Inflammation, Bone Erosion, and Cartilage Destruction, Arthritis Rheum, 50, 1, pp. 277-290, (2004)

[8]

Dayer J.M., Interleukin 1 or Tumor Necrosis Factor-alpha: Which is the Real Target in Rheumatoid Arthritis, J Rheumatol Suppl, 65, pp. 10-15, (2002)

[9]

Avramescu C., Vere C.C., Margaritescu C., Et al., Cytokinic Panel in Rheumatoid Arthritis and Correlation with Histological Patterns of Synovitis-Active Type of Disease, Rom J Morphol Embryol, 46, 2, pp. 87-92, (2005)

[10]

Dayer J.M., The Pivotal Role of Interleukin-1 in the Clinical Manifestations of Rheumatoid Arthritis, Rheumatology (Oxford), 42, SUPPL. 2, (2003)

← 1 2 →