Asthma and PM10

被引：82

作者：

Donaldson K. ^{[1
,2
]}

Gilmour M.I. ^{[3
]}

MacNee W. ^{[2
]}

机构：

[1] Biomedicine Research Group, School of Life Sciences, Napier University, Edinburgh

[2] Edinburgh Lung and the Environment Group Initiative Colt Research Laboratories, University of Edinburgh, Medical School, Edinburgh

[3] Experimental Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC

来源：

Respiratory Research | 2000年 / 1卷 / 1期

关键词：

Air pollution; Asthma; Exacerbation; PM[!sub]10[!/sub;

D O I：

10.1186/rr5

中图分类号：

学科分类号：

摘要：

PM10 (the mass of particles present in the air having a 50% cutoff for particles with an aerodynamic diameter of 10 μm) is the standard measure of particulate air pollution used worldwide. Epidemiological studies suggest that asthma symptoms can be worsened by increases in the levels of PM10. Epidemiological evidence at present indicates that PM10 increases do not raise the chances of initial sensitisation and induction of disease, although further research is warranted. PM10 is a complex mixture of particle types and has many components and there is no general agreement regarding which component(s) could lead to exacerbations of asthma. However pro-inflammatory effects of transition metals, hydrocarbons, ultrafine particles and endotoxin, all present to varying degrees in PM10, could be important. An understanding of the role of the different components of PM10 in exacerbating asthma is essential before proper risk assessment can be undertaken leading to advice on risk management for the many asthmatics who are exposed to air pollution particles.

引用

页码：12 / 15

页数：3

共 26 条

[1]

Pope C.A., Dockery D.W., Schwartz J., Review of epidemiological evidence of health effects of particulate air pollution, Inhalation Toxicol., 7, pp. 1-18, (1995)

[2]

(1995)

[3]

(1995)

[4]

(1999)

[5]

Lipsett M., Hurley S., Ostro B., Air pollution and emergency room visits for asthma in Santa Clara county, California, Environ Health Perspect, 105, pp. 216-222, (1997)

[6]

Peters A., Dockery D.W., Heinrich J., Wichmann H.E., Short-term effects of particulate air pollution on respiratory morbidity in asthmatic children, Eur. Respir. J., 10, pp. 872-879, (1997)

[7]

van der Zee S., Hoek G., Boezen H.M., Schouten J.P., van Wijnen J.H., Brunekreef B., Acute effects of urban air pollution on respiratory health of children with and without chronic respiratory symptoms, Occup. Environ. Med., 56, pp. 802-812, (1999)

[8]

Atkinson R.W., Anderson H.R., Strachan D.P., Bland J.M., Bremmer S.A., Ponce de Leon A., Short-term associations between outdoor air pollution and visits to accident and emergency departments in London for respiratory complaints, Eur. Respir. J., 13, pp. 257-265, (1999)

[9]

Anderson H.R., Ponce de Leon A., Bland J.M., Bower J.S., Emberlin J., Strachan D.P., Air pollution, pollens, and daily admissions for asthma in London 1987-92, Thorax, 53, pp. 842-848, (1998)

[10]

Pope C.A., Dockery D.W., Epidemiology of particle effects, Air Pollution and Health, pp. 673-706, (1999)

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