Sex differences in resting hemodynamics and arterial stiffness following 4 weeks of resistance versus aerobic exercise training in individuals with pre-hypertension to stage 1 hypertension

被引：53

作者：

Collier S.R. ^{[1
]}

Frechette V. ^{[2
]}

Sandberg K. ^{[4
]}

Schafer P. ^{[1
]}

Ji H. ^{[4
]}

Smulyan H. ^{[2
]}

Fernhall B. ^{[3
]}

机构：

[1] Vascular Biology and Autonomic Studies Laboratory, Appalachian State University, Boone, NC 28608

[2] Department of Medicine, SUNY Upstate Medical University, Syracuse, NY 13210

[3] Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801

[4] Center for the Study of Sex Differences in Health, Aging and Disease, Georgetown University, Washington, DC 20057, 4000 Reservoir Road, NW

来源：

Biology of Sex Differences | / 2卷 / 1期

关键词：

Arterial Stiffness; Pulse Wave Velocity; Resistance Exercise; Aerobic Exercise; Forearm Blood Flow;

D O I：

10.1186/2042-6410-2-9

中图分类号：

学科分类号：

摘要：

Background: Hypertension (HTN) exhibits sexual dimorphism; the incidence for women surpasses men during the sixth decade of life, while the pharmacological treatments are less effective and produce more side-effects in women than in men. Aerobic exercise (AE) has been shown to prevent and treat HTN; however, resistance exercise (RE) is not recommended as a strategy to treat HTN. In this study, we investigated the potential sex differences of AE versus RE in a cohort of unmedicated patients with hypertension. Methods: In total, 40 moderately active, pre-hypertensive or stage 1 essential hypertensive male (M) and female (F) participants aged 40 to 60 years were randomly divided into four groups: M AE, M RE, F AE, and F. Each group exercised at moderate intensity, 3 days/week for 4 weeks. Hemodynamic, vascular and blood-flow data were collected before and after exercise training. Results: Men showed a significant increase in central pulse wave velocity following RE while females showed no significant changes (12 ± to 13.9 ± vs. 9.2 ± to 9.6 ± m/s, respectively). RE showed significantly greater increases in peak blood flow when compared to AE (F RE 15 ± to 20 ± vs. F AE 17.5 ± to19.5 ±, M RE 19 ± to 24 ± vs M AE 21 ± to 25 ± ml* 100 ml*min, respectively). In addition, systolic and diastolic BP decreased greater for women following RE when compared to AE whereas men showed comparable decreases in BP following either exercise mode. Conclusion: Moderate-intensity RE training may be a more favorable for women as a treatment option for hypertension because of greater decreases in diastolic BP and significant increases in flow-mediated dilation without concomitant increases in arterial stiffness, compared with their male counterparts. © 2011 Collier et al; licensee BioMed Central Ltd.

引用

共 37 条

[1]

Safar M.E., Smulyan H., Hypertension in women, American Journal of Hypertension, 17, 1, pp. 82-87, (2004)

[2]

Reckelhoff J.F., Gender differences in the regulation of blood pressure, Hypertension, 37, 5, pp. 1199-1208, (2001)

[3]

Collier S.R., Kanaley J.A., Carhart Jr. R., Frechette V., Tobin M.M., Hall A.K., Luckenbaugh A.N., Fernhall B., Effect of 4 weeks of aerobic or resistance exercise training on arterial stiffness, blood flow and blood pressure in pre-and stage-1 hypertensives, Journal of Human Hypertension, 22, pp. 678-686, (2008)

[4]

Layne J.E., Nelson M.E., The effects of progressive resistance training on bone density: A review, Medicine and Science in Sports and Exercise, 31, 1, pp. 25-30, (1999)

[5]

Winett R.A., Carpinelli R.N., Potential health-related benefits of resistance training, Preventive Medicine, 33, 5, pp. 503-513, (2001)

[6]

Lohman T., Going S., Pamenter R., Hall M., Boyden T., Houtkooper L., Ritenbaugh C., Bare L., Hill A., Aickin M., Effects of resistance training on regional and total bone mineral density in premenopausal women: A randomized prospective study, J Bone Miner Res, 10, pp. 1015-1024, (1995)

[7]

Phillips S.A., Das E., Wang J., Pritchard K., Gutterman D.D., Resistance and aerobic exercise protects against acute endothelial impairment induced by a single exposure to hypertension during exertion, J Appl Physiol, 110, pp. 1013-1020, (2011)

[8]

Pierce G.L., Eskurza I., Walker A.E., Fay T.N., Seals D.R., Sex-specific effects of habitual aerobic exercise on brachial artery flow-mediated dilation in middle-aged and older adults, Clin Sci (Lond), 120, pp. 13-23, (2011)

[9]

Ainsworth B.E., Jacobs Jr. D.R., Leon A.S., Validity and reliability of self-reported physical activity status: The Lipid Research Clinics questionnaire, Medicine and Science in Sports and Exercise, 25, 1, pp. 92-98, (1993)

[10]

Katch F., Michael E.D., Horvath S.M., Estimation of body volume by underwater weighing: Description of a simple method, J Appl Physiol, 23, pp. 811-813, (1967)

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