Regulating effects of herb cake-partitioned moxibustion on the expression of p53 and C-myc protein in rats with ulcerative colitis

被引：5

作者：

Zhao T.-P. ^{[1
]}

Wang X.-M. ^{[1
]}

Liu H.-R. ^{[1
]}

Wu H.-G. ^{[1
]}

Zhou S. ^{[1
]}

机构：

[1] Shanghai Research Institute of Acupuncture and Meridian

来源：

Journal of Acupuncture and Tuina Science | 2010年 / 8卷 / 3期

关键词：

Colitis; Genes; p53; Indirect Moixbustion; Proto-Oncogene Proteins C-myc; Ulcerative;

D O I：

10.1007/s11726-010-0395-y

中图分类号：

学科分类号：

摘要：

Objective: To investigate the mechanism of herb cake-partitioned moxibustion treating ulcerative colitis (UC) from the relationship between expression of p53 and C-myc protein, and morbidity of UC. Methods: Rats model of UC was made with immune methods and local stimulation. Forty SD rats were divided into normal, model, herb cake-partitioned, and mild moxibustion group by a random number table, 10 rats in each group. Hanging moxibustion in the mild moxibustion group was applied to Tianshu (ST 25) and Qihai (CV 6) for 10 min. Two moxa cones of herb cake-partitioned moxibustion were applied to the same acupoints respectively, in the herb cake-partitioned moxibustion group. Expression of p53 and C-myc protein was measured with immunohistochemistical method in the colonic tissue of rats with UC. Results: Postive area, strength, and the immunohistochemistry index of the expression of p53 and C-myc protein were found more in the model rats than those in the normal rats (P<0.01), whereas less in the herb cake-partitioned moxibustion and mild moxibustion groups than those in the model group (P<0.01). Conclusion: p53 and C-myc play important roles in the morbidity and development of UC, and herb cake-partitioned moxibustion could regulate the expression of p53 and C-myc protein in the colonic tissue of UC rats. © 2010 Shanghai Research Institute of Acupuncture and Meridian and Springer-Verlag Berlin Heidelberg.

引用

页码：154 / 158

页数：4

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