Antiretroviral adherence in a resource-poor setting.

被引:29
作者
Orrell C. [1 ]
机构
[1] Desmond Tutu HIV Centre, IIDMM, Werner Beit Building-North, Medical School, Observatory, Anzio Road
关键词
Pill Count; Directly Observe Therapy; Medication Event Monitoring System; Virologic Outcome; Expanded Access Program;
D O I
10.1007/s11904-005-0012-8
中图分类号
学科分类号
摘要
Adherence is key to successful antiretroviral therapy (ART). Many countries with increased HIV prevalence and the greatest need for ART have limited health resources. Recent assumptions that the adherence required for successful ART will not be achieved in resource-poor settings have led to calls for caution in expanded access programs. New studies from Africa refute this, showing excellent adherence and virologic outcomes. Major factors contributing to adherence or nonadherence are whether the drug is accessed for free or is self-funded, patient preparedness for use of ART, stigmatization related to being HIV-positive, and ease of use of regimen.
引用
收藏
页码:171 / 176
页数:5
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  • [1] Arnsten JH(2001)Antiretroviral therapy adherence and viral suppression in HIV-infected drug users: comparison of self report and electronic monitoring Clin Inf Dis 33 1417-1423
  • [2] Demas PA(2000)Adherence to protease inhibitors, HIV-1 viral load and development of drug resistance in an indigent population AIDS 14 357-366
  • [3] Farzadegan H(2000)Adherence to protease inhibitor therapy and outcomes inpatients with HIV infection Ann Intern Med 133 21-30
  • [4] Bangsberg D(2001)Adherence to highly active antiretroviral therapy predict virologic outcome at an inner-city immunodeficiency virus clinic Clin Inf Dis 33 700-705
  • [5] Hecht F(2003)Adherence is not a barrier to successful antiretroviral therapy in South Africa AIDS 17 1369-1375
  • [6] Charlebois ED(2001)Impact of adherence to antiretroviral therapy in HIV-1-infected patients at a university public service in Brazil AIDS Patient Care STDS 15 587-593
  • [7] Paterson D(2001)Preventing antiretroviral anarchy in Africa Lancet 358 410-414
  • [8] Swindells S(2002)First, do no harm: a call for emphasizing adherence and HIV prevention interventions in active antiretroviral therapy program in the developing world AIDS 16 676-678
  • [9] Mohr J(2001)HIV drug resistance and implications for the introduction of antiretroviral therapy in resource-poor countries Drug Resist Updat 4 339-346
  • [10] McNabb J(2004)HIV antiretroviral drug resistance in Africa AIDS Rev 6 4-12