Spontaneous pain and brain activity in neuropathic pain: Functional MRI and pharmacologic functional MRI studies

被引：30

作者：

Baliki M.N. ^{[1
]}

Geha P.Y. ^{[1
]}

Vania Apkarian A. ^{[1
]}

机构：

[1] Northwestern University Feinberg School of Medicine, Department of Physiology, Chicago

来源：

Current Pain and Headache Reports | 2007年 / 11卷 / 3期

关键词：

Neuropathic Pain; Pain Intensity; Brain Activity; Complex Regional Pain Syndrome; Alexithymia;

D O I：

10.1007/s11916-007-0187-3

中图分类号：

学科分类号：

摘要：

Functional brain imaging studies in chronic neuropathic pain patients have lagged far behind equivalent studies in acute pain. In the past few years, this trend has begun to shift. This article discusses the novel approach of studying brain activity for spontaneous pain and its modulation by pharmacologic manipulation. We argue that the approach provides a solid methodology for studying clinical (especially neuropathic) pain and patient populations, and moreover, that the latest results using this approach imply that distinct clinical chronic pain conditions seem to involve specific brain circuitry, which is also distinct from the brain activity commonly observed in acute pain. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：171 / 177

页数：6

共 44 条

[1]

Baliki M., Apkarian A.V., The neurological effects of chronic pain, PainEurope, 2, pp. 4-5, (2006)

[2]

Geha P.Y., Apkarian A.V., Brain imaging findings in neuropathic pain, Curr Pain Headache Rep, 9, pp. 184-188, (2005)

[3]

Geha P.Y., Apkarian A.V., Pain and neuroanatomical effects: Evidence for cortical reorganization, Psychiatric Times, 23, pp. 22-24, (2006)

[4]

Apkarian A.V., Bushnell M.C., Treede R.D., Zubieta J.K., Human brain mechanisms of pain perception and regulation in health and disease, Eur J Pain, 9, pp. 463-484, (2005)

[5]

Kupers R., Kehlet H., Brain imaging of clinical pain states: A critical review and strategies for future studies, Lancet Neurol, 5, pp. 1033-1044, (2006)

[6]

Schweinhardt P., Lee M., Tracey I., Imaging pain in patients: Is it meaningful?, Curr Opin Neurol, 19, pp. 392-400, (2006)

[7]

Schweinhardt P., Bountra C., Tracey I., Pharmacological FMRI in the development of new analgesic compounds, NMR Biomed, 19, pp. 702-711, (2006)

[8]

Jackson P.L., Brunet E., Meltzoff A.N., Decety J., Empathy examined through the neural mechanisms involved in imagining how I feel versus how you feel pain, Neuropsychologia, 44, pp. 752-761, (2006)

[9]

Moriguchi Y., Decety J., Ohnishi T., Et al., Empathy and judging other's pain: An fMRI study of alexithymia, Cereb Cortex, (2006)

[10]

Singer T., Seymour B., O'Doherty J., Kaube H., Et al., Empathy for pain involves the affective but not sensory components of pain, Science, 303, pp. 1157-1162, (2004)

← 1 2 3 4 5 →