The metabolic syndrome and related cardiovascular risk

被引:21
作者
Ramos F. [1 ]
Baglivo H.P. [1 ]
Ramírez A.J. [1 ]
Sánchez R. [1 ]
机构
[1] Hypertension Section, ICYCC, Favaloro Foundation, Favaloro University, Belgrano 1746, Buenos Aires
关键词
Insulin Resistance; Metabolic Syndrome; Insulin Sensitivity; Troglitazone; Celiprolol;
D O I
10.1007/s11906-001-0020-z
中图分类号
学科分类号
摘要
The metabolic syndrome is a complex association of several risk factors including insulin resistance, dyslipidemia, and essential hypertension. Insulin resistance has been associated with sympathetic activation and endothelial dysfunction, which are the main mechanisms involved in the pathophysiology of hypertension and its related cardiovascular risk. According to the Sixth Report of the Joint National Committee, and guidelines of the World Health Organization/International Society of Hypertension, the presence of multiple risk markers suggests that both hypertension and risk factors should be aggressively managed in order to obtain a better outcome. Primary prevention of obesity at different levels - individual, familial, and social - starting early in childhood has proven to be cost effective, and will be mandatory to reduce the world epidemic of obesity and its severe consequences. Copyright © 2001 by Current Science Inc.
引用
收藏
页码:100 / 106
页数:6
相关论文
共 71 条
[1]  
Defronzo R.A., Ferranini E., Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia and atheroesclerotic cardiovasular disease, Diabetes Care, 14, pp. 173-194, (1991)
[2]  
Haffner S.M., Epidemiology of insulin resistance and its relation to coronary artery disease, American Journal of Cardiology, 84, (1999)
[3]  
Hall J.E., Summers R.L., Brands M.W., Et al., Resistance to metabolic actions of insulin and its role in hypertension, Am J Hypertens, 7, pp. 772-788, (1994)
[4]  
Sechi L.A., Mechanisms of insulin resistance in rat models of hypertension and their relationships with salt sensitivity, J Hypertens, 17, pp. 1229-1237, (1998)
[5]  
Andersson B., Elam M., Wallin B.G., Et al., Effect of energyrestricted diet on sympathetic mucle nerve activity in obese women, Hypertension, 18, pp. 783-789, (1991)
[6]  
Hall J.E., Pathophysiology of obesity hypertension, Curr Hypertens Rep, 2, pp. 139-147, (2000)
[7]  
Sartori C., Scherrer U., Insulin, nitric oxide and the sympathetic nervous system: At the crossroads of metabolic and cardiovascular regulation, J Hypertens, 17, pp. 1517-1525, (1999)
[8]  
Owlya R., Vollenweider L., Trueb L., Et al., Cardiovascular and sympathetic effects of nitric oxide inhibition at rest and during exercise in humans, Circulation, 96, pp. 3897-3903, (1997)
[9]  
Collins V.R., Dowse G.J., Finch C.F., Et al., An inconsistent relationship between insulin and blood pressure in three Pacific Island populations, J Clin Epidemiol, 43, pp. 1365-1378, (1990)
[10]  
Saad M.F., Lillioja S., Nyomba B.L., Et al., Racial differences in the relation between blood pressure and insulin resistance, N Engl J Med, 324, pp. 733-739, (1991)