Family-based study of markers at the 5′-flanking region of the human dopamine transporter gene reveals potential association with schizophrenic psychoses

被引：12

作者：

Stöber G. ^{[1
]}

Sprandel J. ^{[1
]}

Jabs B. ^{[1
]}

Pfuhlmann B. ^{[1
]}

Möller-Ehrlich K. ^{[1
]}

Knapp M. ^{[2
]}

机构：

[1] Department of Psychiatry and Psychotherapy, University of Würzburg, 97080 Würzburg

[2] Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, 53105 Bonn

来源：

European Archives of Psychiatry and Clinical Neuroscience | 2006年 / 256卷 / 7期

关键词：

Dopamine transporter; Gene; hSLC6A3; Polymorphism; Promoter; Schizophrenia;

D O I：

10.1007/s00406-006-0657-3

中图分类号：

学科分类号：

摘要：

The dopamine hypothesis of schizophrenia proposes an inherited or acquired presynaptic hyperactivity of dopaminergic neurons. The human dopamine transporter gene (hSLC6A3; hDAT) represents one major mechanism for the termination of dopaminergic neurotransmission. This study examines the degree of genetic association of the 5′-untranslated region (5′-UTR) of the hSLC6A3 to schizophrenia in a family-based association design. Five single nucleotide polymorphisms (SNPs) derived by a previous systematic mutation scan ∼1.2 kb of the 5′-UTR of the hSLC6A3 locus were genotyped for transmission disequilibrium between 82 index cases (56 males) with schizophrenia and their biological parents. We observed no preferential transmission of alleles from heterozygous parents to affected offspring. Five estimated haplotypes accounted for a frequency of 90% in the index cases, and were identical in cases and non-transmitted parental control haplotypes. Distinct five-locus-genotypes accumulated in schizophrenia compared to parental controls at P-value 0.0038 with odds-ratio of 2.02 (95% CI 0.99-4.14). In conclusion, our present findings support the genetic involvement of distinct hSLC6A3 genotypes in schizophrenia. We propose replication in extended samples and examination of the functional relevance of the associated genotypes on human dopamine transporter expression. © 2006 Steinkopff Verlag.

引用

页码：422 / 427

页数：5

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