Gene map of the extended human MHC

被引：861

作者：

Roger Horton ^{[1
]}

Laurens Wilming ^{[1
]}

Vikki Rand ^{[1
]}

Ruth C. Lovering ^{[2
]}

Elspeth A. Bruford ^{[2
]}

Varsha K. Khodiyar ^{[2
]}

Michael J. Lush ^{[2
]}

Sue Povey ^{[2
]}

C. Conover Talbot ^{[3
]}

Mathew W. Wright ^{[2
]}

Hester M. Wain ^{[2
]}

John Trowsdale ^{[4
]}

Andreas Ziegler ^{[5
]}

Stephan Beck ^{[1
]}

机构：

[1] Wellcome Trust Sanger Institute, Genome Campus, Hinxton

[2] HUGO Gene Nomenclature Committee, Department of Biology, University College London

[3] HUGO Gene Nomenclature Committee, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore

[4] University of Cambridge, Department of Pathology, Immunology Division, Cambridge CB2 1QP, Tennis Court Road

[5] Institut für Immungenetik, Charite-Universitatsmedizin Berlin, Humboldt-Universität zu Berlin

来源：

Nature Reviews Genetics | 2004年 / 5卷 / 12期

基金：

英国医学研究理事会; 美国国家卫生研究院; 英国惠康基金;

关键词：

D O I：

10.1038/nrg1489

中图分类号：

学科分类号：

摘要：

The major histocompatibility complex (MHC) is the most important region in the vertebrate genome with respect to infection and autoimmunity, and is crucial in adaptive and innate immunity. Decades of biomedical research have revealed many MHC genes that are duplicated, polymorphic and associated with more diseases than any other region of the human genome. The recent completion of several large-scale studies offers the opportunity to assimilate the latest data into an integrated gene map of the extended human MHC. Here, we present this map and review its content in relation to paralogy, polymorphism, immune function and disease.

引用

页码：889 / 899

页数：10

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