What you need to know about GB virus C

被引:11
作者
George S.L. [1 ]
Varmaz D. [1 ]
机构
[1] Division of Infectious Diseases, Saint Louis University School of Medicine, St. Louis, MO 63110, FDT-8N
关键词
West Nile Virus; Classical Swine Fever Virus; Yellow Fever Virus; Infected PBMCs; CCR5 Receptor Expression;
D O I
10.1007/s11894-005-0067-0
中图分类号
学科分类号
摘要
GB virus C (GBV-C) is a nonpathogenic member of the Flaviviridae family most closely related to hepatitis C virus (HCV). Infection is common in healthy and immunocompromised people and may persist for years. GBV-C infection is associated with improved survival, improved AIDSfree survival, higher CD4+ T-cell counts, and lower HIV viral loads in HIV-infected people compared with people infected with HIV but not GBV-C. The mechanism of this effect is not yet clear, but GBV-C has been shown to inhibit HIV replication in vitro through increased synthesis and secretion of anti-HIV β-chemokines MIP-1-a, MIP-1α, RANTES, SDF-1, and SDF-2 and downregulation of CCR5 receptor expression. GBV-C also inhibits apoptosis of its host cell, similar to HCV. GBV-C E2 protein in serum has also been associated with prolonged survival in HIV infection; recent evidence indicates that GBV-C E2 protein may neutralize HIV infection in vitro. © Current Science Inc. 2005.
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页码:54 / 62
页数:8
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