Batch and fed-batch production of butyric acid by Clostridium butyricum ZJUCB

被引：46

作者：

He G.-Q. ^{[1
]}

Kong Q. ^{[1
]}

Chen Q.-H. ^{[1
]}

Ruan H. ^{[1
]}

机构：

[1] Department of Food Science and Nutrition, Zhejiang University

来源：

Journal of Zhejiang University-SCIENCE B | 2005年 / 6卷 / 11期

关键词：

Acetic acid; Batch fermentation; Butyric acid production; Clostridium butyricum; Fed-batch fermentation; pH;

D O I：

10.1631/jzus.2005.B1076

中图分类号：

学科分类号：

摘要：

The production of butyric acid by Clostridium butyricum ZJUCB at various pH values was investigated. In order to study the effect of pH on cell growth, butyric acid biosynthesis and reducing sugar consumption, different cultivation pH values ranging from 6.0 to 7.5 were evaluated in 5-L bioreactor. In controlled pH batch fermentation, the optimum pH for cell growth and butyric acid production was 6.5 with a cell yield of 3.65 g/L and butyric acid yield of 12.25 g/L. Based on these results, this study then compared batch and fed-batch fermentation of butyric acid production at pH 6.5. Maximum value (16.74 g/L) of butyric acid concentration was obtained in fed-batch fermentation compared to 12.25 g/L in batch fermentation. It was concluded that cultivation under fed-batch fermentation mode could enhance butyric acid production significantly (P < 0.01) by C. butyricum ZJUCB.

引用

页码：1076 / 1080

页数：4

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