Gastric infection by Helicobacter pylori

被引：67

作者：

Sachs G. ^{[1
,2
,3
]}

Scott D.R. ^{[2
,3
]}

Wen Y. ^{[2
,3
]}

机构：

[1] Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA

[2] Department of Physiology, David Geffen School of Medicine, UCLA, Los Angeles, CA

[3] Veterans Administration Greater Los Angeles Healthcare System, Bldg. 113, Los Angeles, CA 90073

来源：

Current Gastroenterology Reports | 2011年 / 13卷 / 6期

关键词：

Acid acclimation; Carbonic anhydrase; Cyp2C19; H; K-ATPase; Helicobacter pylori; Peptic ulcer disease; Probiotics; Proton pump inhibitors; Response regulator; Sensor kinase; Two component system; Urease; UreI;

D O I：

10.1007/s11894-011-0226-4

中图分类号：

学科分类号：

摘要：

Helicobacter pylori infects half of the world's population and plays a causal role in ulcer disease and gastric cancer. This pathogenic neutralophile uniquely colonizes the acidic gastric milieu through the process of acid acclimation. Acid acclimation is the ability of the organism to maintain periplasmic pH near neutrality in an acidic environment to prevent a fall in cytoplasmic pH in order to maintain viability and growth in acid. Recently, due to an increase in antibiotic resistance, the rate of H. pylori eradication has fallen below 80% generating renewed interest in novel eradication regimens and targets. In this article, we review the gastric biology of H. pylori and acid acclimation, various detection procedures, antibiotic resistance and the role that gastric acidity plays in the susceptibility of the organism to antibiotics currently in use and propose several novel drug targets that would promote eradication in the absence of antibiotics. © 2011 Springer Science+Business Media, LLC (outside the USA).

引用

页码：540 / 546

页数：6

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