Biological healing of large diaphyseal deep-frozen allograft transplants

被引：8

作者：

Nather A. ^{[1
]}

机构：

[1] National University Hospital Tissue Bank, National University Hospital, Singapore 119074

来源：

Cell and Tissue Banking | 2001年 / 2卷 / 1期

关键词：

Allografts; Biological; Deep-frozen; Diaphyseal; Experimental; Healing;

D O I：

10.1023/A:1011521006118

中图分类号：

学科分类号：

摘要：

The biological healing of large, deep-frozen, diaphyseal allografts was studied in 24 cats. Deep-frozen allograft stored at -80°C was used to replace a large defect, at least two-thirds of the cat's tibial diaphysis. Intra-medullary rod fixation was used. The healing was studied at observation periods of 4, 6, 8, 12, 16, 24 and 36 weeks. Biological parameters studied included microangiography for revascularisation and fracture healing, bone resorption, new bone formation and callus encasement. Deep-frozen allografts united without difficulty by 12 weeks. However, minimal revascularisation of the allograft occurred even at 9 months. Likewise, minimal biological repair activity was seen even at 9 months as shown by the parameters of bone resorption, cortical new bone formation and 'callus encasement'. Biologically, deep-frozen cortical allografts remained inert for a long period of time in the adult cat.

引用

页码：3 / 7

页数：4

共 9 条

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