Matrix metalloproteinase in left ventricular remodeling and heart failure

被引：17

作者：

Suresh Shastry

Melvin R. Hayden

Pamela A. Lucchesi

Suresh C. Tyagi

机构：

[1] Department of Physiology/Biophysics, Univ. of Mississippi Medical Center, Jackson, MS 39216

来源：

Current Cardiology Reports | 2003年 / 5卷 / 3期

基金：

美国国家卫生研究院;

关键词：

Nitric Oxide; Endothelial Cell Density; Myocardial Extracellular Matrix; Cardiac Inhibitor; Proteolytic Stress;

D O I：

10.1007/s11886-003-0049-5

中图分类号：

学科分类号：

摘要：

Accumulation of oxidized matrix between the endothelium and cardiac muscle, and endocardial endothelial dysfunction, are the hallmarks of congestive heart failure. The induction of oxidative stress, decrease in endothelial cell density, activation of matrix and disintegrin metalloproteinase, collagenolysis, and repression of cardiac inhibitor of metalloproteinase (CIMP) are associated with deposition of oxidized matrix. Studies that employ CIMP as genetic or proteomic therapeutic agent may improve the heart's response to nitric oxide donors. Identification of major players involved in the control of oxidative and proteolytic stresses that ameliorate matrix deposition by integrin shading will help to develop strategies to prevent congestive heart failure. Copyright © 2003 by Current Science Inc.

引用

页码：200 / 204

页数：4

共 52 条

[1]

Tyagi S.C., Proteinases and myocardial extracellular matrix turnover, Mol. Cell Biochem., 168, pp. 1-12, (1997)

[2]

Loechel F., Gilpin B.J., Engvall E., Et al., Human ADAM12 (meltrin á) is an active metalloproteinase, J. Biol. Chem., 273, pp. 16993-16997, (1998)

[3]

Hayden M.R., Tyagi S.C., Arteriogenesis: Angiogenesis within unstable atherosclerotic plaque-interactions with extracellular matrix, Curr. Intervent. Cardiol. Report, 2, pp. 218-227, (2000)

[4]

Nagase H., Woessner J.F., Matrix metalloproteinase, J. Biol. Chem., 274, pp. 21491-21494, (1999)

[5]

Wolfsberg T.G., White J.M., ADAMs in fertilization and development, Devel. Biol., 180, pp. 389-401, (1996)

[6]

Tyagi S.C., Dynamic role of extracellular matrix metalloproteinases in heart failure, Cardiovasc. Pathol., 7, pp. 153-159, (1998)

[7]

Hunt M.J., Aru G.M., Hayden M.R., Et al., Induction of oxidative stress and disintegrin metalloproteinase in human heart end-stage failure, Am. J. Physiol., 283, (2002)

[8]

Faury G., Ristori M.T., Verdetti J., Et al., Effect of elastin peptides on vascular tone, J. Vasc. Res., 32, pp. 112-119, (1995)

[9]

Hunt M.J., Tyagi S.C., Peroxisome proliferators compete and ameliorate homocysteine-mediated endocardial endothelial cells activation, Am. J. Physiol. (Cell Physiol.), 283, (2002)

[10]

Mujumdar V.S., Aru G.M., Tyagi S.C., Induction of oxidative stress by homocysteine impairs endothelial function, J. Cell Biochem., 82, pp. 491-500, (2001)

← 1 2 3 4 5 6 →