Lipophilic calcium antagonists in antiatherosclerotic therapy

被引：14

作者：

Bellosta S. ^{[1
,2
]}

Bernini F. ^{[1
,2
]}

机构：

[1] Institute of Pharmacological Sciences, University of Milan

[2] Institute of Pharmacology and Pharmacognosy, University of Parma

来源：

Current Atherosclerosis Reports | 2000年 / 2卷 / 1期

关键词：

Calcium Antagonist; Amlodipine; Cholesteryl Ester; Cholesterol Esterification; Lacidipine;

D O I：

10.1007/s11883-000-0098-9

中图分类号：

学科分类号：

摘要：

Two key events in atherosclerotic plaque formation are the deposition of lipids in cells of the vascular wall, and migration and proliferation of arterial smooth muscle cells from the tunica intima toward the media. It has been shown that various calcium-channel antagonists may delay plaque formation in animal models. Among these, the new and highly lipophilic calcium antagonists, such as lacidipine and lercanidipine, display the most promising antiatherosclerotic activities. This paper will review and discuss these beneficial effects.

引用

页码：76 / 81

页数：5

共 45 条

[1]

Ross, R, Atherosclerosis: an inflammatory disease (1999) N Engl J Med, 340, pp. 115-126

[2]

Falk, E, Shah, PK, Fuster, V, Coronary plaque disruption (1995) Circulation, 92, pp. 657-671

[3]

Loree, HM, Kamm, RD, Stringfellow, RG, Effects of fibrous cap thickness on peak circumferential stress in model atherosclerotic vessels (1992) Circ Res, 71, pp. 850-858

[4]

Richardson, PD, Davies, MJ, Born, GVR, Influence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques (1989) Lancet, 2, pp. 941-944

[5]

Davies, MJ, Richardson, PD, Woolf, N, Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content (1993) Br Heart J, 69, pp. 377-381

[6]

Dollery, CM, McEwan, JR, Henney, AM, Matrix metalloproteinases and cardiovascular disease (1995) Circ Res, 77, pp. 863-868

[7]

Bendeck, MP, Zempo, N, Clowes, AW, Smooth muscle cell migration and matrix metalloproteinase expression after arterial injury in the rat (1994) Circ Res, 75, pp. 539-545

[8]

Bernini, F, Catapano, AL, Corsini, A, Effects of calcium antagonists on lipids and atherosclerosis (1989) Am J Cardiol, 64, pp. 1291-1331

[9]

Henry, PD, Bentley, KI, Suppression of atherogenesis in cholesterol-fed rabbits treated with nifedipine (1981) J Clin Invest, 68, pp. 1366-1369

[10]

Schmitz, G, Hankowitz, J, Kovacs, EM, Cellular processes in atherogenesis: potential targets of Ca2+ channel blockers (1991) Atherosclerosis, 88, pp. 109-132

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