Metformin improves ovulation and pregnancy rates in patients with polycystic ovary syndrome

被引：41

作者：

Batukan C. ^{[1
]}

Baysal B. ^{[2
]}

机构：

[1] Universitätsfrauenklinik, Kantonspital, Basel

[2] Department of Obstetrics and Gynaecology, Istanbul Faculty of Medicine, University of Istanbul, Suadiye 81070, Istanbul

来源：

Archives of Gynecology and Obstetrics | 2001年 / 265卷 / 3期

关键词：

Metformin; Ovulation induction; Polycystic ovary syndrome;

D O I：

10.1007/s004040100176

中图分类号：

学科分类号：

摘要：

We evaluated the fertility promoting effect of metformin in infertile patients with polycystic ovary syndrome. Twenty-nine infertile patients with polycystic ovary syndrome (PCOS) are included in our prospectively designed study and 15 normal menstruating women served as controls for reproductive hormones and ovarian volumes. All PCOS patients received a total of 78 cycles of clomiphene citrate (CC) in the beginning, then patients who could not get pregnant were switched to metformin plus clomiphene citrate. PCOS patients served as their own controls for the ovulation and pregnancy rates. At the end of the CC cycles 4.2% of patients got pregnant and 65.2% of the remaining group got pregnant with metformin plus CC cycles (p=0.0001). We have not observed any serious side effects of metformin. The high pregnancy rate of our study population is consistent with the hypothesis that insulin resistance plays an important role in the pathogenesis of anovulation in patients with PCOS.

引用

页码：124 / 127

页数：3

共 17 条

[1]

Armstrong A.B., Hoeldtke N., Weiss T.E., Metabolic parameters that predict response to clomiphene citrate in obese oligo-ovulatory women, Military Med, 161, pp. 732-734, (1996)

[2]

Bailey C.J., Turner R.C., Metformin drug therapy, N Engl J Med, 334, pp. 574-576, (1996)

[3]

Bergh C., Carlsson B., Olsson J.-H., Selleskog U., Hillensjo T., Regulation of androgen production in cultured human thecal cells by insulin-like growth factor and insulin, Fertil Steril, 59, pp. 323-325, (1993)

[4]

Diamanti E., Kandanallis E., Kouli C., Banateli T., Bergiele A., Therapeutic effects of metformin on insulin resistance and hyperandrogenisim in PCOS, Eur J Endocrinol, 138, pp. 269-274, (1998)

[5]

Dunaif A., Xia J., Book C.B., Schenker E., Tang Z., Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome, J Clin Invest, 96, pp. 801-810, (1995)

[6]

Espinosa de los Monteros A., Ayala J., Sanabrial C., Serum insulin in clomiphene responders and non-responders with polycystic ovarian disease, Rev Invest Clin, 47, pp. 347-353, (1995)

[7]

Franks S., Polycystic ovary syndrome, N Engl J Med, 333, pp. 853-861, (1995)

[8]

Kim L.H., Taylor A.E., Barbieri R.L., Insulin sensitizers and polycystic ovary syndrome: Can a diabetes medication treat infertility?, Fertil Steril, 73, pp. 1097-1098, (2000)

[9]

Mitwally M.F., Kuscu N.K., Yalcinkaya T.M., High ovulatory rates with use of troglitazone in clomiphene-resistant women with polycystic ovary syndrome, Hum Reprod, 14, pp. 2700-2703, (1999)

[10]

Moran C., Carranza-Lira S., Noyola J.E., Garcia-Hernandez E., Henao G., Bermudez J.A., Effect of clomiphene citrate on ovulation after treatment withdrawal, Arch Gynecol Obstet, 261, pp. 117-120, (1998)

← 1 2 →