Chromosomal regions harboring genes for the work to femur failure in mice

被引：20

作者：

Li X. ^{[1
,2
]}

Masinde G. ^{[1
,2
]}

Gu W. ^{[1
,2
]}

Wergedal J. ^{[1
,2
]}

Hamilton-Ulland M. ^{[1
,2
]}

Xu S. ^{[1
,2
]}

Mohan S. ^{[1
,2
]}

Baylink D.J. ^{[1
,2
]}

机构：

[1] Molecular Genetics Division, Musculoskeletal Disease Center, Loma Linda University, Loma Linda, CA 92357

[2] Department of Botany and Plant Sciences, University of California, Riverside

来源：

Functional & Integrative Genomics | 2002年 / 1卷 / 6期

关键词：

Bone mineral density; Instron; Quantitative trait loci; Work to failure;

D O I：

10.1007/s10142-001-0045-z

中图分类号：

学科分类号：

摘要：

The work to failure is defined as the maximum energy bone can absorb before breaking, and therefore is a direct test of the risk of fracture. To determine the genetic loci influencing work to failure, we have performed a high density genome-wide scan in 633 (MRL× SJL) F2 female mice. Five loci (P < 0.005) with significant effects on work to failure were found on chromosomes 2, 7, 8, 9, and X, which collectively explained around 20% variance of work to femur failure in F2 mice. Of those, only the QTL on chromosome 9 was concordant with bone mineral density (BMD) QTLs. Eight significant interactions (P < 0.01) between marker loci were identified, which accounted for an equivalent amount of F2 variance (23%) to combined single QTL effects. Our results demonstrate that most of the genetic loci regulating work to failure are different from those for BMD in the 7-week-old female mice. If this is also true in humans, this finding will challenge the predictive value of BMD for the risk of fracture.

引用

页码：367 / 374

页数：7

共 20 条

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