Parathyroid hormone and bone biomechanics

被引：9

作者：

Allen M.R. ^{[1
]}

Burr D.B. ^{[1
,2
,3
,4
]}

机构：

[1] Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN

[2] Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN

[3] Biomedical Engineering Program, Indiana University-Purdue University, Indianapolis, IN

[4] Department of Anatomy and Cell Biology, MS-5035, Indianapolis, IN 46202

来源：

Clinical Reviews in Bone and Mineral Metabolism | 2006年 / 4卷 / 4期

关键词：

Bone geometry; Mechanical properties; Teriparatide; Trabecular architecture;

D O I：

10.1385/BMM:4:4:259

中图分类号：

学科分类号：

摘要：

Parathyroid hormone (PTH) treatment, either in the form of teriparatide or recombinant human PTH(1-34), reduces the fracture risk of osteoporotic women by enhancing both structural and material biomechanical properties. Cortical bone thickness and cross-sectional moment of inertia increase because of new bone formation on periosteal and endocortical surfaces. Intracortical porosity is increased yet preferential localization near the endocortical surface limits any negative biomechanical effects. Greater trabecular bone volume results from a positive basic multicellular unit bone balance and renewed modeling. Initial increases in trabecular thickness are eventually reduced as a result of trabecular tunneling, increasing trabecular number, and connectivity. These geometrical and architectural alterations are the predominant mechanism by which PTH increases structural strength, stiffness, and energy absorption. PTH also positively alters material-level strength, modulus, and toughness. These changes are counterintuitive based on known effects of decreasing average tissue mineralization and increasing tissue heterogeneity. This combination of enhanced structural and material biomechanical properties makes PTH an effective treatment for reducing fracture risk despite smaller gains in bone mineral density compared to other osteoporosis agents. © Copyright 2006 by Humana Press Inc. All rights of any nature whatsoever reserved.

引用

页码：259 / 268

页数：9

共 52 条

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