Tubulointerstitial immune complex nephritis in a patient with systemic lupus erythematosus: Role of peritubular capillaritis with immune complex deposits in the pathogenesis of the tubulointerstitial nephritis

被引：18

作者：

Hayakawa S. ^{[1
]}

Nakabayashi K. ^{[1
]}

Karube M. ^{[1
]}

Arimura Y. ^{[1
]}

Soejima A. ^{[1
]}

Yamada A. ^{[1
]}

Fujioka Y. ^{[2
]}

机构：

[1] First Department of Internal Medicine, Kyorin University School of Medicine, Mitaka, Tokyo 181-0086

[2] Department of Pathology, Kyorin University School of Medicine, Tokyo

来源：

Clinical and Experimental Nephrology | 2006年 / 10卷 / 2期

关键词：

Immune complex; Peritubular capillaritis; Sjögren syndrome; Systemic lupus erythematosus; Tubulointerstitial nephritis;

D O I：

10.1007/s10157-006-0405-z

中图分类号：

学科分类号：

摘要：

Class IV-G (A/C) diffuse lupus nephritis and tubulointerstitial (TI) nephritis in a 31-year old woman was studied by light, immunofluorescence (IF), and electron microscopy (EM), to determine the pathogenesis of the TI lesions. The light microscopic findings showed peritubular capillaritis in the interstitium, with ruptures in the capillary structure, lysis of the surrounding tubular basement membrane (TBM), extravasated red blood cells (RBCs), the infiltration of neutrophils and mononuclear cells, and edema. The IF study revealed IgG, IgA, IgM, C1q, C3, and C4 depositions along the TBM, on the capillary walls, and in the interstitium proper. The EM study disclosed the deposition of immune complexes in the TBM, the capillary wall, and the interstitium proper. Based on these findings, the TI nephritis in this patient was considered to be due to peritubular capillaritis secondary to the immune complex depositions in the capillary wall of the interstitium. © Japanese Society of Nephrology 2006.

引用

页码：146 / 151

页数：5

共 23 条

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