The crystal structure of cricket paralysis virus: The first view of a new virus family

被引：98

作者：

Tate J. ^{[1
,2
]}

Liljas L. ^{[1
,3
]}

Scotti P. ^{[4
]}

Christian P. ^{[5
]}

Lin Tianwei ^{[1
]}

Johnson J.E. ^{[1
]}

机构：

[1] Department of Molecular Biology, Scripps Research Institute, San Diego, CA 92037

[2] San Diego Supercomputer Center, University of California, San Diego, San Diego, CA 92093-0505

[3] Department of Molecular Biology, University of Uppsala, Uppsala

[4] Hort. Food Res. Inst. New Zealand L., Mt. Albert Research Centre, Auckland

[5] CSIRO Division of Entomology, Canberra 2601

来源：

Nature Structural Biology | 1999年 / 6卷 / 8期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/11543

中图分类号：

学科分类号：

摘要：

Numerous small, RNA-containing insect viruses are currently classified as picornaviruses, or as 'picorna-like', since they superficially resemble the true picornaviruses. Considerable evidence now suggests that several of these viruses are members of a distinct family. We have determined the gene sequence of the capsid proteins and the 2.4 Å resolution crystal structure of the cricket paralysis virus. While the genome sequence indicates that the insect picorna-like viruses represent a distinct lineage compared to true picornaviruses, the capsid structure demonstrates that the two groups are related. These viral genomes are, thus, best viewed as composed of exchangeable modules that have recombined.

引用

页码：765 / 774

页数：9

共 9 条

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