Age-related changes in plasma levels of BDNF in Down syndrome patients

被引：26

作者：

Dogliotti G. ^{[1
,2
]}

Galliera E. ^{[1
,2
]}

Licastro F. ^{[1
,2
]}

Corsi M.M. ^{[1
,2
,3
]}

机构：

[1] Department of Human Morphology and Biomedical Sciences Città Studi, Laboratory of Clinical Pathology, University of Milan, Milan

[2] Department of Experimental Pathology, Laboratory of Immunology, University of Bologna, Bologna

[3] Laboratory of Biotechnological Applications, IRCCS Istituto Galeazzi, Milan

来源：

Immunity & Ageing | / 7卷 / 1期

关键词：

Nerve Growth Factor; Down Syndrome; BDNF Level; Adult Control; Down Syndrome Patient;

D O I：

10.1186/1742-4933-7-2

中图分类号：

学科分类号：

摘要：

Background: The prevalence of coronary artery diseases is low among Down Syndrome (DS) patients and they rarely die of atherosclerotic complications. Histopathological investigations showed no increase in atherosclerosis, or even a total lack of atherosclerotic changes, in DS. Aim: The aim of our study is to investigate the relationship between age and brain-derived neurotrophic factor (BDNF) levels in Down Syndrome (DS).Subjects and methods: Three groups of DS patients were studied: the first consisted of 23 children (age 2-14 years); the second of 14 adults (age 20-50 years), the third group of 13 elderly persons (>60 years) and a controls group of 20 healthy patients (age 15-60 years).The analytes of interest were quantified using a biochip array analyzer (Evidence®, Randox Ltd., Crumlin, UK).Results: Plasma BDNF was higher in DS patients than in controls and there was a significant age-related increase. Serum levels of IL-6 and MCP-1 were also higher in DS children and adults, but not in older patients, than in healthy control. High levels of circulating BDNF may protect DS patients from the clinical complications of atherosclerosis. However, the striking drop in peripheral BDNF levels with age might predispose these patients to clinical manifestations of dementia in later life. © 2010 Dogliotti et al; licensee BioMed Central Ltd.

引用

共 15 条

[1]

Pueschel S.M., Craig W.Y., Haddow J.E., Lipids and lipoproteins in persons with Down's syndrome, J Intellect Disabil Res, 36, PART 4, pp. 365-369, (1992)

[2]

Murdoch J.C., Rodger J.C., Rao S.S., Fletcher C.D., Dunnigan M.G., Down's syndrome: An atheroma-free model?, British medical journal, 2, pp. 226-228, (1977)

[3]

Chaldakov G.N., Fiore M., Stankulov I.S., Manni L., Hristova M.G., Antonelli A., Ghenev P.I., Aloe L., Neurotrophin presence in human coronary atherosclerosis and metabolic syndrome: A role for NGF and BDNF in cardiovascular disease?, Progress in brain research, 146, pp. 279-289, (2004)

[4]

Corsi M.M., Dogliotti G., Pedroni F., Palazzi E., Magni P., Chiappelli M., Licastro F., Plasma nerve growth factor (NGF) and inflammatory cytokines (il-6 and mcp-1) in young and adult subjects with down syndrome: An interesting pathway, Neuro endocrinology letters, 27, pp. 773-778, (2006)

[5]

Chaldakov G.N., Fiore M., Stankulov I.S., Hristova M., Antonelli A., Manni L., Ghenev P.I., Angelucci F., Aloe L., NGF, BDNF, leptin, and mast cells in human coronary atherosclerosis and metabolic syndrome, Archives of physiology and biochemistry, 109, pp. 357-360, (2001)

[6]

Chaldakov G.N., Fiore M., Hristova M.G., Aloe L., Metabotrophic potential of neurotrophins: Implication in obesity and related diseases?, Med Sci Monit, 9, (2003)

[7]

Gardiner K., Predictions for altered protein complex stoichiometries and post-translational modifications, and consequences for learning/behavior genes elk, creb, and the estrogen and glucocorticoid receptors, Behavior genetics, 36, pp. 439-453, (2006)

[8]

Sohrabji F., Lewis D.K., Implications for neurodegenerative diseases, Frontiers in neuroendocrinology, 27, pp. 404-414, (2006)

[9]

Licastro F., Chiappelli M., Ruscica M., Carnelli V., Corsi M.M., Altered cytokine and acute phase response protein levels in the blood of children with downs syndrome: Relationship with dementia of alzheimer's type, International journal of immunopathology and pharmacology, 18, pp. 165-172, (2005)

[10]

Manni L., Di Fausto V., Chaldakov G.N., Aloe L., Brain leptin and nerve growth factor are differently affected by stress in male and female mice: Possible neuroendocrine and cardio-metabolic implications, Neuroscience letters, 426, pp. 39-44, (2007)

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