Brainstem in multiple system atrophy: Clinicopathological correlations

被引：70

作者：

Eduardo E. Benarroch ^{[1
]}

机构：

[1] Department of Neurology, Mayo Clinic, Rochester, MN 55905

来源：

Cellular and Molecular Neurobiology | 2003年 / 23卷 / 4-5期

关键词：

Autonomic failure; MSA; Neurogenic bladder; REM sleep;

D O I：

10.1023/A:1025067912199

中图分类号：

学科分类号：

摘要：

1. Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder that manifests with parkinsonism, cerebellar ataxia, and autonomic failure in various combinations. 2. Orthostatic hypotension, neurogenic bladder, laryngeal stridor and sleep apnea, and rapid eye movement (REM) sleep behavior disorder are prominent manifestations of MSA. 3. In MSA, there is severe depletion of catecholaminergic neurons of the C1 and A1 areas in the ventrolateral medulla, and this may contribute to orthostatic hypotension and endocrine disturbances in this disorder, respectively. 4. Loss of corticotrophin-releasing factor (CRF) neurons in the pontine micturition area may contribute to neurogenic bladder dysfunction. 5. Respiratory abnormalities may reflect loss of cholinergic neurons in the arcuate nucleus of the ventral medulla. 6. Loss of cholinergic mesopontine neurons, in the setting of loss of locus ceruleus neurons and preservation of rostral raphe neurons, may contribute to REM sleep abnormalities in MSA.

引用

页码：519 / 526

页数：7

共 42 条

[1]

Bannister R., Multiple system atrophy and pure autonomic failure, Clinical Autonomic Disorders: Evaluation and Management, pp. 517-526, (1993)

[2]

Bannister R., Gibson W., Michaels L., Oppenheimer D.R., Laryngeal abductor paralysis in multiple system atrophy. A report on three necropsied cases, with observations on the laryngeal muscles and the nucleus ambiguus, Brain, 104, pp. 351-368, (1981)

[3]

Benarroch E.E., Schmeichel A.M., Parisi J.E., Involvement of the ventrolaterol medulla in Parkinsonism with autonomic failure, Neurology, 54, pp. 963-968, (2000)

[4]

Benarroch E.E., Schmeichel A.M., Depletion of corticotrophin-releasing factor neurons in the pontine micturition area in multiple system atrophy, Ann. Neurol., 50, pp. 640-645, (2001)

[5]

Benarroch E.E., Schmeichel A.M., Parisi J.E., Depletion of cholinergic neurons of the medullary arcuate nucleus in multiple system atrophy, Auton. Neurosci., 87, pp. 293-299, (2001)

[6]

Benarroch E.E., Schmeichel A.M., Parisi J.E., Depletion of mesopontine cholinergic and sparing of raphe neurons in multiple system atrophy, Neurology, 59, pp. 944-946, (2002)

[7]

Benarroch E.E., Smithson I.L., Low P.A., Parisi J.E., Depletion of catecholaminergic neurons of the rostral ventrolateral medulla in multiple systems atrophy with autonomic failure, Ann. Neurol., 43, pp. 156-163, (1998)

[8]

Blessing W.W., The Lower Brainstem and Bodily Homeostasis, (1997)

[9]

Blessing W.W., Willoughby J.O., Central neural pathways mediating baroreceptor-initiated secretion of vasopressin, Cardiogenic Reflexes, pp. 301-317, (1987)

[10]

Chandiramani V.A., Fowler C.J., Urogenital disorders in Parkinson's disease and multiple system atrophy, Neurology of Bladder, Bowel, and Sexual Dysfunction, pp. 245-254, (1999)

← 1 2 3 4 5 →