Plasticity of human adipose stem cells toward endothelial cells and cardiomyocytes

被引：91

作者：

Fraser J.K. ^{[1
,2
]}

Schreiber R. ^{[1
]}

Strem B. ^{[1
]}

Zhu M. ^{[1
]}

Alfonso Z. ^{[1
]}

Wulur I. ^{[1
]}

Hedrick M.H. ^{[1
]}

机构：

[1] Cytori Therapeutics Inc., San Diego, CA

[2] San Diego, CA 92121

来源：

Nature Clinical Practice Cardiovascular Medicine | 2006年 / 3卷 / Suppl 1期

关键词：

Adipose; Cell theraphy; Stem cells;

D O I：

10.1038/ncpcardio0444

中图分类号：

学科分类号：

摘要：

Recent preclinical and clinical studies have suggested that adult stem cells have the ability to promote the retention or restoration of cardiac function in acute and chronic ischemia. Published clinical studies have used autologous donor cells, including skeletal muscle myoblasts, cultured peripheral blood cells, or bone marrow cells. However, our research and that of others indicates that human adipose tissue is an alternative source of cells with potential for cardiac cell therapy. These findings include the presence of cells within adipose tissue that can differentiate into cells expressing a cardiomyocytic or endothelial phenotype, as well as angiogenic and antiapoptotic growth factors. This potential is supported by preclinical studies in large animals. © 2006 Nature Publishing Group.

引用

页码：S33 / S37

页数：4

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