Influenza infection and risk of acute pulmonary embolism

被引：39

作者：

van Wissen M. ^{[1
,2
]}

Keller T.T. ^{[1
]}

Ronkes B. ^{[1
]}

Gerdes V.E.A. ^{[1
,2
]}

Zaaijer H.L. ^{[3
]}

van Gorp E.C.M. ^{[2
]}

Brandjes D.P.M. ^{[2
]}

Levi M. ^{[1
]}

Büller H.R. ^{[1
]}

机构：

[1] Department of Vascular Medicine, Academic Medical Center, Amsterdam

[2] Department of Internal Medicine, Slotervaart Hospital, Amsterdam

[3] Department of Microbiology, Academic Medical Center, Amsterdam

来源：

Thrombosis Journal | / 5卷 / 1期

关键词：

Chronic Obstructive Pulmonary Disease; Influenza; Pulmonary Embolism; Venous Thromboembolism; Acute Respiratory Infection;

D O I：

10.1186/1477-9560-5-16

中图分类号：

学科分类号：

摘要：

Background: Influenza infections have been associated with procoagulant changes. Whether influenza infections lead to an increased risk of pulmonary embolism remains to be established. Methods: We conducted a nested case control study in a large cohort of patients with a clinical suspicion of having pulmonary embolism. Blood samples were collected to investigate the presence of influenza A and B by complement fixation assay (CFA). We compared case patients, in whom pulmonary embolism was proven (n = 102), to controls, in whom pulmonary embolism was excluded (n = 395). Furthermore, we compared symptoms of influenza-like illness in both patient groups 2 weeks prior to inclusion in the study, using the influenza-like illness (ILI) score, which is based on a questionnaire. We calculated the risk of pulmonary embolism associated with influenza infection. Results: The percentage of patients with influenza A was higher in the control group compared to the case group (4.3% versus 1.0%, respectively, odds ratio 0.22; 95% CI: 0.03-1.72). Influenza B was not detectable in any of the cases and was found in 3 of the 395 controls (0.8%). The ILI score was positive in 24% of the cases and 25% in the control persons (odds ratio 1.16, 95% CI: 0.67-2.01). We did not observe an association between the ILI score and proven influenza infection. Conclusion: In this clinical study, influenza infection was not associated with an increased risk of acute pulmonary embolism. The ILI score is non-specific in this clinical setting. © 2007 van Wissen et al; licensee BioMed Central Ltd.

引用

共 18 条

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