Towards understanding the presence/absence of Human African Trypanosomosis in a focus of Côte d'Ivoire: A spatial analysis of the pathogenic system

被引：20

作者：

Courtin F. ^{[1
,2
,5
]}

Jamonneau V. ^{[2
]}

Oké E. ^{[1
]}

Coulibaly B. ^{[1
]}

Oswald Y. ^{[3
]}

Dupont S. ^{[2
]}

Cuny G. ^{[2
]}

Doumenge J.-P. ^{[4
]}

Solano P. ^{[1
,2
]}

机构：

[1] Institut Pierre Richet (IPR), Équipe THA et Glossines, Abidjan 04

[2] Institut de Recherche pour le Développement, Unité de Recherche UR 177, Laboratoire de Recherche et de Coordination sur les Trypanosomoses (LRCT IRD-CIRAD), 34398 Montpellier Cedex 5, Campus International de Baillarguet

[3] University of Lille, USTL/LGMA (Laboratoire de Géographie des Milieux Anthropisés), UMR CNRS 8141, Lille

[4] University of Montpellier 3, UFR Sciences Humaines et Sciences de l'Environnement, Laboratoire de Recherche GESTER (Gestion des Territoires et des Risques), 34199 Montpellier Cedex 5, route de Mende

[5] IRD, Bobo-Dioylasso 01

来源：

International Journal of Health Geographics | / 4卷 / 1期

关键词：

Trypanosoma Brucei; Geographic Information System Analysis; Cocoa Plantation; Colonial Administration; Entomological Survey;

D O I：

10.1186/1476-072X-4-27

中图分类号：

学科分类号：

摘要：

Background: This study aimed at identifying factors influencing the development of Human African Trypanosomosis (HAT, or sleeping sickness) in the focus of Bonon, located in the mesophile forest of Côte d'Ivoire. A previous study mapping the main daytime activity sites of 96 patients revealed an important disparity between the area south of the town- where all the patients lived- and the area north of the town, apparently free of disease. In order to explain this disparity, we carried out a spatial analysis of the key components of the pathogenic system, i.e. the human host, the tsetse vector and the trypanosomes in their environment using a geographic information system (GIS). Results: This approach at the scale of a HAT focus enabled us to identify spatial patterns which linked to the transmission and the dissemination of this disease. The history of human settlement (with the rural northern area exploited much earlier than the southern one) appears to be a major factor which determines the land use pattern, which itself may account for differences found in vector densities (tsetse were found six times more abundant in the southern rural area than in the northern). Vector density, according to the human and environmental context in which it is found (here an intense mobility between the town of Bonon and the rural areas), may explain the observed spatial differences in HAT prevalence. Conclusions: This work demonstrates the role of GIS analyses of key components of the pathogenic system in providing a better understanding of transmission and dissemination of HAT. Moreover, following the identification of the most active transmission areas, and of an area unfavourable to HAT transmission, this study more precisely delineates the boundaries of the Bonon focus. As a follow-up, targeted tsetse control activities starting north of Bonon (with few chances of reinvasion due to very low densities) going south, and additional medical surveys in the south will be proposed to the Ivoirian HAT control program to enhance the control of the disease in this focus. This work also shows the evolution of HAT regarding time and environment, and the methodology used may be able to predict possible sleeping sickness development/extinction in areas with similar history and space organization. © 2005 Courtin et al., licensee BioMed Central Ltd.

引用

页数：27

共 26 条

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