Adjuvant therapy for high-risk renal cell carcinoma patients

被引：26

作者：

Kunkle D.A. ^{[1
]}

Haas N.B. ^{[1
]}

Uzzo R.G. ^{[1
]}

机构：

[1] Department of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111

来源：

Current Urology Reports | 2007年 / 8卷 / 1期

基金：

英国医学研究理事会;

关键词：

Renal Cell Carcinoma; Clin Oncol; Sorafenib; Sunitinib; Metastatic Renal Cell Carcinoma;

D O I：

10.1007/s11934-007-0017-5

中图分类号：

学科分类号：

摘要：

For most cases of renal cell carcinoma (RCC), the standard of care is surgical resection as monotherapy or as part of a multimodal approach. In patients with early localized disease, radical nephrectomy is associated with a favorable prognosis, whereas patients with advanced disease are rarely cured. A significant number of patients undergoing surgery for localized RCC experience recurrence, suggesting that there are some individuals in whom surgical excision is necessary but insufficient. In these patients, the development of effective adjuvant strategies is imperative. In this article, we review the prognostic variables and comprehensive staging algorithms for identifying patients at high risk for disease recurrence. Additionally, we review data from completed adjuvant RCC trials and highlight relevant ongoing trials. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：19 / 30

页数：11

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