Microalbuminuria as a predictor of early glomerular injury in children with sickle cell disease

被引：25

作者：

Vikram Datta

Janaki Raju Ayengar

Shilpaja Karpate

Pushpa Chaturvedi

机构：

[1] Department of Pediatrics, Mahatma Gandhi Inst. of Med. Sci., Wardha, Maharashtra

[2] Department of Pediatrics, Lady Hardinge Medical College

来源：

The Indian Journal of Pediatrics | 2003年 / 70卷 / 4期

关键词：

Glomerulus; Kidney; Microalbumin; Sickle cell;

D O I：

10.1007/BF02723586

中图分类号：

学科分类号：

摘要：

Objective: A cross sectional study was carried out to determine the prevalence of microalbuminuria in the pediatric patients with sickle cell disease. Methods: The study was carried out on 64 pediatric patients aged less than 14 years with documented HbSS, HbAS and HbS beta thalassemia, Microalbuminuria was estimated using single radial immuno diffusion technique. Majority of the study subjects were of HbSS type. 38.5% had symptoms for >2 years. 18.8% of the study population had significant microalbuminuria (19.2% of SS types and 18.8% of Hb AS types). Result: Microalbuminuria excretion was significantly more in patients >9 years of age as compared to young patients (p<0.05). Mean serum creatinine levels did not show any significant difference in the various study groups. Conclusion: Microalbuminuria estimation is a very important clinical marker of preclinical glomerular damage in patients with sickle cell disease. Its estimation would help in the early detection of such patients and prompt initiation of therapy.

引用

页码：307 / 309

页数：2

共 14 条

[1]

Bourke E., The kidney in sickle cell disease, J Assoc Acad Minor Phys, 3, 2, pp. 41-45, (1992)

[2]

Aoki R.Y., Saad S., Microalbuminuria in sickle cell disease, Braz J Med Biol Res, 23, 11, pp. 1103-1106, (1990)

[3]

Mogensen C.E., Hansen K.W., Nielsen S., Pedersen M.M., Rehling M., Schmitz A., Monitoring diabetic nephropathy: Glomerular filtration rate and abnormal albuminuria in diabetic renal disease - Reproductivity, progression and efficacy of antihypertensive intervention, Am J Kidney Dis, 22, 1, pp. 174-187, (1993)

[4]

Guasch A., Sickle Cell Information Center Guidelines-Proteinuria and Renal Insufficiency

[5]

Sesso R., Almeida M.A., Figueiredo M.S., Bordin J.O., Renal dysfunction in patients with sickle cell anemia or sickle cell trait, Braz J Med Biol Res, 31, 10, pp. 1257-1262, (1998)

[6]

Wigfall D.R., Ware R.E., Burchinal M.R., Kinney T.R., Foreman J.W., Prevelance and clinical correlates of glomerulopathy in children with sickle cell disease, J Pediatr, 136, 6, pp. 749-753, (2000)

[7]

Dharnidharka V.R., Dabbagh S., Atiyeh B., Simpson P., Sarnaik S., Prevalence of microalbuminuria in children with sickle cell disease, Pediatr Nephrol, 12, 6, pp. 475-478, (1998)

[8]

Allon M., Renal abnormalities in sickle cell disease, Arch Intern Med, 150, 3, pp. 501-504, (1990)

[9]

Allon M., Lawson L., Eckman J.R., Delaney V., Bourke E., Effects of non-steroidal anti-inflammatory drugs on renal function in sickle cell anemia, Kidney Int, 34, pp. 500-506, (1988)

[10]

Verani R.R., Conley S.B., Sickle cell glomerulopathy with focal segmental glomerulosclerosis, Child Nephrol Urol, 11, 4, pp. 206-208, (1991)

← 1 2 →