Analysis of the fusion protein gene of the porcine rubulavirus LPMV: Comparative analysis of paramyxovirus F proteins

被引：14

作者：

Berg M. ^{[1
]}

Bergvall A.-C. ^{[1
]}

Svenda M. ^{[1
]}

Sundqvist A. ^{[1
]}

Moreno-López J. ^{[1
]}

Linné T. ^{[1
]}

机构：

[1] Dept. of Veterinary Microbiology, Swed. Univ. of Agricultural Sciences, Biomedical Center, 5-751 23, Uppsala

来源：

Virus Genes | 1997年 / 14卷 / 1期

关键词：

Fusion; Glycoprotein; La-Piedad-Michoacan-Mexico virus; Phylogenetic analysis; Porcine; Rubulavirus;

D O I：

10.1023/A:1007987407250

中图分类号：

学科分类号：

摘要：

Complementary DNA clones representing the fusion (F) protein gene of the porcine rubulavirus LPMV were isolated and sequenced. The F gene was found to be 1845 nucleotides long containing one long open reading frame capable of encoding a protein of 541 amino acids. The cleavage motif for F0 into F1 and F2 is His-Arg-Lys-Lys-Arg. A sequence comparison and a phylogenetic analysis was performed in order to identify possible functional domains of paramyxovirus fusion proteins and also to classify the porcine rubulavirus. The F gene of LPMV is most closely related to the human mumps virus and simian virus type 5 F genes, and is therefore classified into the rubulavirus genus. A coding region for a small hydrophobic protein was however not found between the F and hemagglutinin-neuraminidase (HN) genes as previously found in both SV5 and mumps.

引用

页码：55 / 61

页数：6

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