T cells in psoriatic arthritis

被引：16

作者：

Choy E. ^{[1
]}

机构：

[1] Academic Department of Rheumatology, King's College London, Weston Education Center, London, SE5 9PJ, Cutcombe Road

来源：

Current Rheumatology Reports | 2007年 / 9卷 / 6期

关键词：

Psoriasis; Ectopic Lymphoid Neogenesis; Heral Blood;

D O I：

10.1007/s11926-007-0071-5

中图分类号：

学科分类号：

摘要：

Psoriatic arthritis is characterized by chronic inflammation of the skin and synovial joint. T cells are abundant in the inflamed joint and skin. Disease susceptibility is associated with major histocompatibility complex, which presents antigens to T cells. T cells in the synovial joints have an activated phenotype and demonstrate selective T-cell receptor usage suggestive of oligoclonal expansions. Taken together, these facts suggest that psoriatic arthritis is driven by antigen or autoantigen-driven T-cell activation. The therapeutic benefit of anti-T-cell agents further supports an important pathogenic role for T cells in persistent synovial inflammation and joint damage in psoriatic arthritis. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：437 / 441

页数：4

共 35 条

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