Autologous fat grafts: Can we match the donor fat site and the host environment for better postoperative outcomes and safety?

被引：6

作者：

Dani C. ^{[1
]}

Foissac R. ^{[1
,2
]}

Ladoux A. ^{[1
]}

Chignon-Sicard B. ^{[1
,3
]}

机构：

[1] Université Côte d’Azur, CNRS, Inserm, iBV, Faculté de Médecine, Cedex 2, Nice

[2] Plastic and Aesthetic Surgery Centre, Saint-Georges Clinic, Nice

[3] Plastic, Reconstructive and Hand Surgery Department, Hôpital Pasteur 2, Nice

来源：

Current Surgery Reports | / 5卷 / 7期

关键词：

Adipose stem cells; Breast reconstruction; Fat grafting; Tissue regeneration Fat depots;

D O I：

10.1007/s40137-017-0178-1

中图分类号：

学科分类号：

摘要：

Purpose of Review Autologous fat grafting is the gold standard for soft tissue repair. The donor fat depot is chosen where a surplus of subcutaneous fat is found. However, the adipose tissues from different parts of the body are not equivalent. Despite the heterogeneity in fat depots, it is still considered that any adipose tissue site is a suitable fat depot donor for transplantation. Recent Findings Matching embryonic origins and Hox code between transplanted stem cells and the host microenvironment emerges as a critical parameter to achieve correct repair in different preclinical models. It has also recently been reported that the individual fat depots routinely used in reconstructive surgery exhibit distinct embryonic origins and express different HOX code. An opposite gradient from the upper to the lower body exists between expressions of HOXC10 and the neural crest marker PAX3. This observation raises the question of the choice for the best fat donor site. Summary Matching between the host tissue and the donor fat sites is a factor that urgently deserves consideration to improve postoperative outcomes and safety of autologous fat grafting. © Springer Science + Business Media New York 2017.

引用

共 39 条

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