Preoperative administration of intravenous flurbiprofen axetil reduces postoperative pain for spinal fusion surgery

被引：225

作者：

Yamashita K. ^{[1
]}

Fukusaki M. ^{[1
]}

Ando Y. ^{[1
]}

Fujinaga A. ^{[1
]}

Tanabe T. ^{[1
]}

Terao Y. ^{[1
]}

Sumikawa K. ^{[2
]}

机构：

[1] Department of Anesthesia, Nagasaki Rosai Hospital, Sasebo 857-0134

[2] Division of Anesthesiology, Department of Translational Medical Science, Nagasaki University School of Medicine, Nagasaki

来源：

Journal of Anesthesia | 2006年 / 20卷 / 2期

关键词：

Flurbiprofen axetil; Opioid-sparing effect; Postoperative pain;

D O I：

10.1007/s00540-006-0389-6

中图分类号：

学科分类号：

摘要：

Purpose: The aim of the study was to investigate postoperative analgesia and the opioid-sparing effect of the preoperative administration of intravenous flurbiprofen axetil in patients undergoing spinal fusion surgery. Methods: Thirty-six patients were randomly allocated into one of three groups. Group A received preoperative flurbiprofen axetil, 1 mg·kg-1. Group B received postoperative flurbiprofen axetil, 1mg·kg-1. Group C received a placebo. All groups were given a standardized anesthesia and intravenous morphine via a patient-controlled analgesia device for postoperative analgesia. The pain score was evaluated by a visual analog scale (VAS) at 0 (T0), 1 (T1), 2 (T2), 6 (T3), 12 (T4), and 24 (T5) h after surgery, and the morphine requirement was recorded during the study period. Results: VAS in group A was significantly lower than that in group B at T0 and T1. VAS in group A was significantly lower than that in group C throughout the time course after surgery. Postoperative morphine consumption in group A was significantly lower than that in groups B and C at T0 to T3. Conclusion: As compared with postoperative administration, preoperative administration of intravenous flurbiprofen axetil provides better postoperative analgesia and an opioid-sparing effect in patients undergoing spinal fusion surgery under general anesthesia. © JSA 2006.

引用

页码：92 / 95

页数：3

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