The role of antibiotic prophylaxis on wound infection after mesh hernia repair under local anesthesia on an ambulatory basis

被引：11

作者：

Celdrán A. ^{[1
,4
]}

Frieyro O. ^{[1
]}

de la Pinta J.C. ^{[2
]}

Souto J.L. ^{[1
]}

Esteban J. ^{[3
]}

Rubio J.M. ^{[1
]}

Señarís J.F. ^{[1
]}

机构：

[1] Department of General Surgery, Clin. Nuestra Senora la Concepcion, Universidad Autonoma de Madrid, Madrid

[2] Ambulatory Care Unit, Clin. Nuestra Senora la Concepcion, Universidad Autonoma de Madrid, Madrid

[3] Department of Microbiology, Clin. Nuestra Senora la Concepcion, Universidad Autonoma de Madrid, Madrid

[4] 6Serv. de Cir. del Aparato Digestivo, 28040 Madrid

来源：

Hernia | 2004年 / 8卷 / 1期

关键词：

Antibiotic; Local anesthesia; Mesh repair;

D O I：

10.1007/s10029-003-0164-7

中图分类号：

学科分类号：

摘要：

Mesh prosthesis, local anesthesia, and ambulatory care have been widely introduced in recent decades in the treatment of inguinal hernia. The use of antibiotic prophylaxis during open inguinal hernia repair has been controversial. No prospective trial has been conducted to assess the role of antibiotic prophylaxis in patients operated on for inguinal hernia under the above-mentioned conditions. A prospective, randomized, double-blinded trial was initiated to assess the efficacy of antibiotic prophylaxis in the prevention of wound infection during open mesh inguinal hernia repair under local anesthesia on an ambulatory basis. Ninety-nine consecutive hernia repairs were randomized to receive 1 g of parenteral Cefazolin preoperatively or a placebo. No wound infections existed in the therapeutic group (0/50). Four infections appeared in the control group (4/49), and the study was suspended for ethical reasons when differences reached values close to statistical significance (P = 0.059). We conclude that a single dose of intravenous Cefazolin decreases the risk of wound infection during open mesh inguinal hernia repair under local anesthesia on an ambulatory basis. © Springer-Verlag 2003.

引用

页码：20 / 22

页数：2

共 13 条

[1]

Mc Vay C.B., The anatomic basis for inguinal and femoral hernioplasty, Surg. Gynecol. Obstet., 139, pp. 931-945, (1974)

[2]

Celdran A., Vorwald P., Merono E., Garcia-Urena M.A., A single technique for polypropylene mesh repair of inguinal and femoral hernias, Surg. Gynecol. Obstet., 175, pp. 359-361, (1992)

[3]

Davis J.E., The major ambulatory surgical center and how it is developed, Surg. Clin. North Am., 67, pp. 671-692, (1987)

[4]

Amid P.K., Shulman A.G., Lichtenstein I.L., Local anesthesia for inguinal hernia repair step-by-step procedure, Ann. Surg., 220, pp. 735-737, (1994)

[5]

Troy M.G., Dong Q., Dobrin P.B., Hecht D., Do topical antibiotics provide prophylaxis against bacterial growth in the presence of polypropylene mesh?, Am. J. Surg., 171, pp. 391-393, (1996)

[6]

Platt R., Zaleznik D.F., Hopkins C.C., Et al., Perioperative antibiotic prophylaxis for herniorrhaphy and breast surgery, N. Engl. J. Med., 322, pp. 153-160, (1990)

[7]

Lazorthes F., Chiotasso P., Massip P., Et al., Local antibiotic prophylaxis in inguinal hernia repair, Surg. Gynecol. Obstet., 175, pp. 569-570, (1992)

[8]

Taylor E.W., Byrne D.J., Leaper D.J., Et al., Antibiotic prophylaxis and open groin hernia repair, World J. Surg., 21, pp. 811-815, (1977)

[9]

Yerdel M.A., Akin E.B., Dolalan S., Turkcapar A.G., Pehlivan M., Gecim I.E., Kuterdem E., Effect of single-dose prophylactic Ampicillin and Sulbactam on wound infection after tension-free inguinal hernia repair with polypropylene mesh, Ann. Surg., 233, pp. 26-33, (2001)

[10]

Mann D.V., Prout J., Havranek E., Gould S., Darzi A., Late-onset deep prosthetic infection following mesh repair of inguinal hernia, Am. J. Surg., 176, pp. 12-14, (1998)

← 1 2 →