The genomic aspect of virulence, sepsis, and resistance to killing mechanisms in Staphylococcus aureus

被引：27

作者：

Cheung A.L. ^{[1
]}

Projan S.J. ^{[1
]}

Gresham H. ^{[1
]}

机构：

[1] Department of Microbiology, Dartmouth Medical School, Vail 206, Hanover, 03755, NH

来源：

Current Infectious Disease Reports | 2002年 / 4卷 / 5期

关键词：

Cell Wall Protein; Phylococcus Aureus; SCCmec Element; Staphylococcus Aureus; Virulence Determinant;

D O I：

10.1007/s11908-002-0006-2

中图分类号：

学科分类号：

摘要：

Staphylococcus aureus is widely appreciated as a pathogen, despite the fact that this microorganism is usually a benign colonizer of the host, rarely if ever causing infection. However, this bacterium, in response to changing environments, will occasionally switch from a commensal to a lethal pathogen. S. aureus uses an array of two-component signal transduction systems, winged-helix transcription proteins, and alternate sigma factor to create an intricate network of regulation in response to environmental change/stimuli. The interactions between members of this large cast of regulatory elements are beginning to be appreciated. Predicated upon recent genomic data, this review focuses on how this regulatory apparatus functions to control the expression of the multitude of virulence factors this "Jekyl and Hyde" organism produces. © 2002, Current Science Inc.

引用

页码：400 / 410

页数：10

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