The renin-angiotensin system and insulin resistance

被引：53

作者：

Liu Z. ^{[1
]}

机构：

[1] Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908-1410

来源：

Current Diabetes Reports | 2007年 / 7卷 / 1期

关键词：

Insulin Resistance; Endothelial Dysfunction; Losartan; Valsartan; Ramipril;

D O I：

10.1007/s11892-007-0007-5

中图分类号：

学科分类号：

摘要：

Insulin resistance upregulates the renin-angiotensin system (RAS), which contributes to the pathogenesis hypertension, heart failure, and atherosclerosis. RAS inhibition decreases cardiovascular and renal morbidity and mortality and the incidence of new-onset type 2 diabetes. To the same degree, angiotensin II impairs insulin signaling, induces inflammation via the nuclear factor-κB pathway, and reduces nitric oxide availability and facilitates vasoconstriction, leading to insulin resistance and endothelial dysfunction. Thus, the RAS, insulin resistance, and inflammation perpetuate each other and coordinately contribute to endothelial dysfunction, vascular injury, and atherosclerosis. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：34 / 42

页数：8

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