Effects of triptolide from Radix Tripterygium wilfordii (Leigongteng) on cartilage cytokines and transcription factor NF-κB: A study on induced arthritis in rats

被引：31

作者：

Xiao C. ^{[1
,2
]}

Zhou J. ^{[2
]}

He Y. ^{[3
]}

Jia H. ^{[2
]}

Zhao L. ^{[2
]}

Zhao N. ^{[2
]}

Lu A. ^{[2
,4
]}

机构：

[1] Institute of Clinical Medicine Research, China-Japan Friendship Hospital

[2] Institute of Basic Theory, China Academy of Traditional Chinese Medicine

[3] National Pharmaceutical Engineering Centre for Herbal Preparations, Jiangxi University of Traditional Chinese Medicine, Nanchang

[4] E-institutes of Shanghai Municipal Education Commission, Shanghai University of Traditional Chinese Medicine

来源：

Chinese Medicine | / 4卷 / 1期

基金：

中国国家自然科学基金;

关键词：

Rheumatoid Arthritis; Articular Cartilage; Collagen Induce Arthritis; Rheumatoid Arthritis Synovial Fibroblast; Arthritic Score;

D O I：

10.1186/1749-8546-4-13

中图分类号：

学科分类号：

摘要：

Background: Triptolide, an active compound of Radix Tripterygium wilfordii, is immunosuppressive, cartilage protective and anti-inflammatory both in human and animal studies of various inflammatory and autoimmune diseases, including rheumatoid arthritis, but its therapeutic mechanism remains unclear. The aim of this study is to investigate the effects of triptolide on cartilage cytokines in the CIA model. Methods: Sprague Dawley rats were immunized with type II collagen and orally administered with triptolide. The arthritic scores and incidence changes of the rats were observed. The expression of TNF-α, IL-6, COX-2 and NF-κB in paw cartilage was studied with immunohistochemical staining. Results: Triptolide, at both high and low doses, significantly lowered the arthritic scores, delayed the onset of arthritis and lowered the arthritis incidence. Triptolide treatment at both high and low doses lowered the expression of TNF-α, IL-6, COX-2 and NF-κB in paw cartilage in arthritic rats. Conclusion: Triptolide lowers the arthritic scores, delays the onset of collagen induced arthritis and reduces the expressions of TNF-α, IL-6, NF-κB and COX-2 in paw cartilage in arthritic rats. © 2009 Xiao et al; licensee BioMed Central Ltd.

引用

共 25 条

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