Relationship between dopamine system genes and extraversion and novelty seeking

被引：84

作者：

Golimbet V.E. ^{[1
]}

Alfimova M.V. ^{[1
]}

Gritsenko I.K. ^{[2
]}

Ebstein R.P. ^{[2
]}

机构：

[1] Scientific Center for Mental Health, Russian Academy of Medical Sciences, Moscow

[2] Department of Psychology, Scheinfeld Center of Human Genetics, Hebrew University, Jerusalem

来源：

Neuroscience and Behavioral Physiology | 2007年 / 37卷 / 6期

基金：

俄罗斯基础研究基金会;

关键词：

Catechol-O-methyltransferase; Dopamine; Dopamine receptor; Extraversion; Gene polymorphism; Novelty-seeking; Reinforcement system;

D O I：

10.1007/s11055-007-0058-8

中图分类号：

学科分类号：

摘要：

Dopamine transmission is known to play an important role in the reinforcement system of the brain. Studies have identified dopamine system genes whose polymorphic variants have been linked with the intensity of psychological traits reflecting the tendency to form behaviors characterized by impulsivity and the need for additional stimulation. The aim of the present work was to seek associations between polymorphisms in the catechol-O-methyltransferase (COMT) and D4 dopamine receptor (DRD4) genes and personality traits in the Russian population. Studies of 130 subjects showed that carriers of the Met/Met genotype of the COMT gene had a greater intensity of the novelty-seeking trait than carriers of the Val/Val and Val/Met genotypes, though this association was seen only in women. In addition, the presence of the C allele of the DRD4 gene in carriers of the Met/Met genotype showed high levels of extraversion and hypomania. These results are consistent with current theoretical concepts of the regulation of dopamine transmission in the brain. © Springer Science+Business Media, Inc. 2007.

引用

页码：601 / 606

页数：5

共 30 条

[1]

Golimbet V.E., Gritsenko I.K., Alfimova M.V., Ebstein R.P., Polymorphic markers of the promoter region of the D4 dopamine receptor gene and temperament in mentally healthy humans from the Russian population, Genetika, 41, 7, pp. 966-972, (2005)

[2]

Bilder R.M., Volavka J., Lachman H.M., Grace A.A., The catechol-O-methyltransferase polymorphism: Relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes, Neuropsychopharmacology, 29, 11, pp. 1943-1961, (2004)

[3]

Bookman E.B., Taylor R.E., Adams-Campbell L., Kittles R.A., DRD4 promoter SNPs and gender effects on Extraversion in African Americans, Mol. Psychiatry, 7, 7, pp. 786-789, (2002)

[4]

Chen J., Lipska B.K., Halim N., Ma Q.D., Matsumoto M., Melhem S., Kolachana B.S., Hyde T.M., Herman M.M., Apud J., Egan M.F., Kleinman J.E., Weinberger D.R., Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): Effects on mRNA, protein, and enzyme activity in postmortem human brain, Amer. J. Hum. Genet., 75, 5, pp. 807-821, (2004)

[5]

Ebstein R.P., Novick O., Umansky R., Priel B., Osher Y., Blaine D., Bennett E.R., Nemanov L., Katz M., Belmaker R.H., Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking, Nat. Genet., 12, 1, pp. 78-80, (1996)

[6]

Ekelund J., Suhonen J., Jarvelin M.R., Peltonen L., Lichtermann D., No association of the -521 C/T polymorphism in the promoter of DRD4 with novelty seeking, Mol. Psychiatry, 6, 6, pp. 618-719, (2001)

[7]

Gogos J.A., Morgan M., Luine V., Santha M., Ogawa S., Pfaff D., Karayiorgou M., Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior, Proc. Natl. Acad. Sci. USA, 95, 17, pp. 9991-9996, (1998)

[8]

Herken H., Erdal M.E., Catechol-O-methyltransferase gene polymorphism in schizophrenia: Evidence for association between symptomatology and prognosis, Psychiatr. Genet., 11, 2, pp. 105-109, (2001)

[9]

Kauhanen J., Hallikainen T., Tuomainen T.P., Koulu M., Karvonen M.K., Aalonen J.T., Association between the functional polymorphism of catechol-O-methyltransferase gene and alcohol consumption among social drinkers, Alcoholism: Clin. Exptl. Res., 24, pp. 135-139, (2000)

[10]

Lachman H.J., Nolan K.A., Mohr P., Saito T., Volavka J., Association between catechol O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder, Amer. J. Psychiatry, 155, pp. 835-837, (1998)

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