Transcranial magnetic stimulation for the treatment of depression in neurologic disorders

被引：26

作者：

Fregni F. ^{[1
]}

Pascual-Leone A. ^{[1
]}

机构：

[1] Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215

来源：

Current Psychiatry Reports | 2005年 / 7卷 / 5期

关键词：

Transcranial Magnetic Stimulation; Repetitive Transcranial Magnetic Stimulation; rTMS Treatment; Frequency rTMS; Sham rTMS;

D O I：

10.1007/s11920-005-0041-4

中图分类号：

学科分类号：

摘要：

Depression is commonly as sociated with neurologic disorders. Although depression in neurologic conditions often is associated with a negative impact on quality of life, it frequently is poorly managed. Some factors, such as a multidrug regimen, lack of efficacy, and side effects of antidepressants may explain why depression is not adequately treated in patients with neurologic disorders. Therefore, this population needs new approaches for depression treatment, and repetitive transcranial magnetic stimulation (rTMS) may be one of them because it has been shown to be effective for the treatment of depression alone and depression in certain neurologic diseases such as Parkinson's disease and stroke. rTMS is a noninvasive, focal, and painless treatment associated with few, mild side effects. It may be effective in the treatment of neurologic diseases such as Parkinson's disease, stroke, and epilepsy. In this paper, we discuss the potential risks and benefits of rTMS treatment for depression in Parkinson's disease, epilepsy, stroke, multiple sclerosis, and Alzheimer's disease. Lastly, a framework that includes the parameters of stimulation (intensity, frequency, number of pulses, and site of stimulation) for the treatment of depression in neurologic diseases is proposed. Copyright © 2005 by Current Science Inc.

引用

页码：381 / 390

页数：9

共 110 条

[1]

Pascual-Leone A., Valls-Sole J., Brasil-Neto J.P., Et al., Akinesia in Parkinson's disease. II. Effects of subthreshold repetitive transcranial motor cortex stimulation, Neurology, 44, pp. 892-898, (1994)

[2]

Conca A., Koppi S., Konig P., Et al., Transcranial magnetic stimulation: A novel antidepressive strategy?, Neuropsychobiology, 34, pp. 204-207, (1996)

[3]

George M.S., Wassermann E.M., Kimbrell T.A., Et al., Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: A placebo-controlled crossover trial, Am. J. Psychiatry, 154, pp. 1752-1756, (1997)

[4]

Koppi S., Conca A., Swoboda E., Konig P., Transcranial magnetic stimulation in depressed patients: A new antidepressive therapeutic principle? Presentation of a pilot trial, Wien. Med. Wochenschr., 146, pp. 49-54, (1996)

[5]

Pascual-Leone A., Rubio B., Pallardo F., Catala M.D., Rapid-rate transcranial magnetic stimulation of left dorsolateral prefrontal cortex in drug-resistant depression, Lancet, 348, pp. 233-237, (1996)

[6]

Mansur C., Fregni F., Boggio P.S., Et al., A sham-stimulation controlled trial of rTMS of the unaffected hemisphere on hand motor function after stroke, Neurology, 64, pp. 1802-1804, (2005)

[7]

Siebner H.R., Tormos J.M., Ceballos-Baumann A.O., Et al., Low-frequency repetitive transcranial magnetic stimulation of the motor cortex in writer's cramp, Neurology, 52, pp. 529-537, (1999)

[8]

Fregni F., Thome-Souza S., Bermpohl F., Et al., Antiepileptic effects of repetitive TMS in patients with cortical malformations: An EEG and clinical study, Stereotact. Func. Neurosurgery, (2005)

[9]

Menkes D.L., Bodnar P., Ballesteros R.A., Swenson M.R., Right frontal lobe slow frequency repetitive transcranial magnetic stimulation (SF r-TMS) is an effective treatment for depression: A case-control pilot study of safety and efficacy, J. Neurol. Neurosurg. Psychiatry, 67, pp. 113-115, (1999)

[10]

Theodore W.H., Hunter K., Chen R., Et al., Transcranial magnetic stimulation for the treatment of seizures: A controlled study, Neurology, 59, pp. 560-562, (2002)

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