Clinical and cost-effectiveness of continuous subcutaneous terbutaline versus oral tocolytics for treatment of recurrent preterm labor in twin gestations

被引：19

作者：

Lam F. ^{[1
]}

Bergauer N.K. ^{[2
]}

Jacques D. ^{[2
]}

Coleman S.K. ^{[2
]}

Stanziano G.J. ^{[2
]}

机构：

[1] California Pacific Medical Center, San Francisco, CA

[2] Matria Healthcare, Department of Clinical Research, Marietta, GA

来源：

Journal of Perinatology | 2001年 / 21卷 / 7期

关键词：

D O I：

10.1038/sj.jp.7210553

中图分类号：

学科分类号：

摘要：

Objective: To compare the clinical and cost-effectiveness of treating recurrent preterm labor with continuous subcutaneous terbutaline versus oral tocolytics in twin gestations. Study Design: In a retrospective, matched-cohort design, twin pregnancies treated as outpatients with continuous subcutaneous terbutaline were identified from a perinatal database, then matched 1:1 by gestational age at recurrent preterm labor to those receiving oral tocolytics. There were 353 patients per treatment group. A cost model was used to compare antepartum hospital, nursery, and outpatient charges. Results: Infants of the subcutaneous terbutaline group had greater gestational age at delivery, higher birth weights, and less frequent neonatal intensive care unit admission. Charges for antepartum hospitalization and nursery were significantly less in the subcutaneous terbutaline group, while charges for outpatient services were less for the oral group. Mean total estimated charges were US$17,109 less for those receiving subcutaneous terbutaline. Conclusion: Improved clinical outcomes and decreased nursery utilization suggest cost-effectiveness of outpatient continuous subcutaneous terbutaline versus oral tocolytics for the treatment of recurrent preterm labor.

引用

页码：444 / 450

页数：6

共 25 条

[1]

Ventura S.J., Martin J.A., Curtin S.C., Mathews T.J., 47, (1999)

[2]

Callahan T.L., Hall J.E., Ettner S.L., Christiansen C.L., Greene M.F., Crowley W.F., The economic impact of multiple-gestation pregnancies and the contribution of assisted reproduction techniques to their incidence, N Engl J Med, 331, pp. 244-249, (1994)

[3]

Levene M.I., Wild J., Steer P., Higher multiple births and the modern management of infertility in Britian, Br J Obstet Gynecol, 146, pp. 862-868, (1992)

[4]

Ettner S.L., Christiansen C.L., Callahan T.L., Hall J.E., How low birth weight and gestational age contribute to increased inpatient costs for multiple births, Inquiry, 34, pp. 325-339, (1997)

[5]

Goldenberg R.L., Iams J.D., Miodovnik M., Et al., The preterm prediction study: Risk factors in twin gestations, Am J Obstet Gynecol, 175, pp. 1047-1053, (1996)

[6]

Luke B., The changing pattern of multiple births in the United States: Maternal and infant characteristics, 1973-1990, Obstet Gynecol, 84, pp. 101-106, (1994)

[7]

Luke B., Keith L.G., The contribution of singletons, twins and triplets to low birth weight, infant mortality and handicap in the United States, J Reprod Med, 37, pp. 661-666, (1992)

[8]

Derom R., Derom C., Vlietinck R., Van Maele G., Van Den Berghe H., Twin pregnancies after medically assisted reproduction: Epidemiology, comparative perinatal morbidity and mortality, J Perinat Med, 19, SUPPL. 1, pp. 229-233, (1991)

[9]

(1997)

[10]

Special problems of multiple gestation, (1998)

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