Serum uric acid-lowering therapies: where are we heading in management of hyperuricemia and the potential role of uricase.

被引：59

作者：

Bomalaski J.S. ^{[1
]}

Clark M.A. ^{[1
]}

机构：

[1] Medical College of Pennsylvania Hospital, Drexel University College of Medicine, 3300 Henry Avenue, Philadelphia, 19129, PA

来源：

Current Rheumatology Reports | 2004年 / 6卷 / 3期

关键词：

Uric Acid; Gout; Losartan; Allopurinol; Fenofibrate;

D O I：

10.1007/s11926-004-0075-3

中图分类号：

学科分类号：

摘要：

Although allopurinol has been available for approximately 50 years, hyperuricemia and its sequelae are not only prevalent, but the incidence and costs associated with this disorder continue to increase. However, several new therapies have been developed. Recombinant urate oxidase has been useful in the treatment of tumor lysis hyperuricemia, and pegylated urate oxidase shows promise in patients with hyperuricemia and gout. Febuxostat and Y-700 are new oral xanthine oxidase inhibitors that are in human clinical trials. Tailoring of antilipid therapy in selected hyperuricemic and hyperlipidemic patients with fenofibrate may be of benefit in lowering blood cholesterol and uric acid levels. Similarly, treatment of selected hyperuricemic patients who also are hypertensive with losartan or amlodipine may be beneficial in lowering blood pressure and hyperuricemia. Despite these advances, new treatments for hyperuricemia are needed.

引用

页码：240 / 247

页数：7

共 211 条

[1]

Arrondee E(2002)Epidemiology of gout: is the incidence rising J Rheumatol 29 2403-2406

[2]

Michet CJ(2003)Primary gout in Shantou: a clinical and epidemiological study Chin Med J 116 66-69

[3]

Crowson CS(2003)Trends in the manifestations of gout in Taiwan Rheumatology 42 1529-1533

[4]

Zeng Q(2003)The epidemiology of hyperuricemia in children of Taiwan aborigines J Rheumatol 30 841-845

[5]

Wang Q(2003)Predictors of mortality following heart transplantation: Spanish Registry of Heart Transplantation 1984–2001 Transplant Proc 35 1946-1950

[6]

Ren C(2003)Chronic renal dysfunction after liver transplantation in adult patients: prevalence, risk factors, and impact on mortality Transplant Proc 35 1907-1908

[7]

Chen SY(2003)Is there a pathogenetic role for uric acid in hypertension and renal disease Hypertension 41 1183-1190

[8]

Chen CL(2003)The elevated prevalence of apolipoprotein E2 in patients with gout is associated with reduced renal excretion of urates Rheumatology 42 468-472

[9]

Shen ML(2003)Clinical practice: gout N Engl J Med 349 1647-1655

[10]

Kamatani N(2003)Gout JAMA 289 2857-2860

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