Infections, vaccinations, and the risk of childhood leukaemia

被引：100

作者：

Dockerty J.D. ^{[1
,2
]}

Skegg D.C.G. ^{[2
]}

Elwood J.M. ^{[2
]}

Herbison G.P. ^{[2
]}

Becroft D.M.O. ^{[3
]}

Lewis M.E. ^{[4
]}

机构：

[1] Childhood Cancer Research Group, University of Oxford, Oxford OX2 6HJ

[2] Department of Preventive Medicine, University of Otago, Dunedin

[3] Department of Obstetrics, University of Auckland, National Women's Hospital, Epsom, Auckland, Claude Road

[4] Department of Paediatrics, Wellington School of Medicine, Wellington South

来源：

British Journal of Cancer | 1999年 / 80卷 / 9期

关键词：

Case-control studies; Epidemiology; Infection; Influenza; Leukaemia; Vaccination;

D O I：

10.1038/sj.bjc.6690548

中图分类号：

学科分类号：

摘要：

A nationwide case-control study was conducted in New Zealand, to test hypotheses about the role of infections in the aetiology of childhood leukaemia. Children aged 0-14 years with leukaemia were matched on age and sex to controls selected from birth records. Case ascertainment was virtually complete and 121 (92%) of 131 eligible case families took part. The participation rate among the 303 first-choice eligible controls was 69%. Home interviews and serological tests were conducted. Adjusted relative risks were estimated by logistic regression. There was an increased risk of leukaemia in relation to reported influenza infection of the child during the first year of life (adjusted odds ratio 6.8, 95% confidence interval 1.8-25.7). This could be a chance finding due to multiple comparisons, and it should be tested elsewhere. Some key variables relevant to Greaves' hypothesis were not associated with B-cell precursor acute lymphoblastic leukaemia (numbers of infections and vaccinations, firstborn status, attendance at preschool groups), although a small effect could not be ruled out with a study of this size. Leukaemia risk was higher among children in poorer social circumstances, and this was true for all eligible children as well as for the participants.

引用

页码：1483 / 1489

页数：6

共 16 条

[1] Bithell J.E., Draper G.J., Gorbach P.D., Association between malignant disease in children and maternal virus infections, Br Med J, 1, pp. 706-708, (1973)
[2] Breslow N.E., Day N.E., Statistical Methods in Cancer Research, Vol I The Analysis of Case-Control Studies, 1, (1980)
[3] Dimmock N.J., Primrose S.B., Introduction to Modern Virology, 4th Edn., (1994)
[4] Dockerty J.D., The Epidemiology of Childhood Leukaemia in New Zealand, with Particular Reference to Hypotheses Related to An Infective Cause, pp. 1-535, (1997)
[5] Dockerty J.D., Elwood J.M., Skegg D.C.G., Herbison G.P., Electromagnetic field exposures and childhood cancers in New Zealand, Cancer Causes Control, 9, pp. 299-309, (1998)
[6] Fedrick J., Alberman E.D., Reported influenza in pregnancy and subsequent cancer in the child, Br Med J, 2, pp. 485-498, (1972)
[7] Greaves M.F., Speculations on the cause of childhood acute lymphoblastic leukemia, Leukemia, 2, pp. 120-125, (1988)
[8] Greaves M.F., Alexander F.E., An infectious etiology for common acute lymphoblastic leukaemia in childhood?, Leukemia, 7, pp. 349-360, (1993)
[9] Hamajima N., Hirose K., Inoue M., Takezaki T., Kuroishi T., Tajima K., Case-control studies: Matched control or all available controls?, J Clin Epidemiol, 47, pp. 971-975, (1994)
[10] Kinlen I., Evidence for an infective cause of childhood leukaemia: Comparison of a Scottish new town with nuclear reprocessing sites in Britain, Lancet, 2, pp. 1323-1327, (1988)

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