Recent insights into the role of tumor necrosis factor in the failing heart

被引：117

作者：

Mann D.L. ^{[1
]}

机构：

[1] Winters Center for Heart Failure Research, Department of Medicine, Baylor College of Medicine

来源：

Heart Failure Reviews | 2001年 / 6卷 / 2期

关键词：

Cytokine; Heart failure; Tumor necrosis factor;

D O I：

10.1023/A:1011449708842

中图分类号：

学科分类号：

摘要：

Recent studies have identified the importance of biologically active molecules such as neurohormones in disease progression in heart failure. More recently it has become apparent that in addition to neurohormones, another portfolio of biologically active molecules termed cytokines, are also expressed in the setting of heart failure. This article will review recent clinical and experimental material which suggests that tumor necrosis factor (TNF), a pro-inflammatory cytokine, may contribute to disease progression in heart failure by virtue of the direct toxic effects that this molecule exerts on the heart and circulation.

引用

页码：71 / 80

页数：9

共 58 条

[1]

Carswell E.A., Old L.J., Kassel R.L., Et al., An endotoxin-induced serum factor that causes necrosis of tumors, Proc Natl Acad Sci USA, 72, pp. 3666-3670, (1975)

[2]

Old L.J., Tumor necrosis factor (TNF), Science, 230, pp. 630-632, (1985)

[3]

Yokoyama T., Nakano M., Bednarczyk J.L., Et al., Tumor necrosis factor-α provokes a hypertrophic growth response in adult cardiac myocytes, Circulation, 95, pp. 1247-1252, (1997)

[4]

Yokoyama T., Vaca L., Rossen R.D., Et al., Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart, J Clin Invest, 92, pp. 2303-2312, (1993)

[5]

Gulick T.S., Chung M.K., Pieper S.J., Et al., Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte β-adrenergic responsiveness, Proc Natl Acad Sci USA, 86, pp. 6753-6757, (1989)

[6]

Giroir B.P., Johnson J.H., Brown T., Et al., The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia, J Clin Invest, 90, pp. 693-698, (1992)

[7]

Kapadia S., Lee J.R., Torre-Amione G., Et al., Tumor necrosis factor gene and protein expression in adult feline myocardium after endotoxin administration, J Clin Invest, 96, pp. 1042-1052, (1995)

[8]

Kapadia S., Oral H., Lee J., Et al., Hemodynamic regulation of tumor necrosis factor-α gene and protein expression in adult feline myocardium, Circ Res, 81, pp. 187-195, (1997)

[9]

Torre-Amione G., Kapadia S., Lee J., Et al., Expression and functional significance of tumor necrosis factor receptors in human myocardium, Circulation, 92, pp. 1487-1493, (1995)

[10]

Torre-Amione G., Kapadia S., Lee J., Et al., Tumor necrosis factor-α and tumor necrosis factor receptors in the failing human heart, Circulation, 93, pp. 704-711, (1996)

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