The role of anticonvulsants in preventive migraine therapy

被引：17

作者：

Jill Corbo

机构：

[1] Department of Emergency Medicine, Jacobi Medical Center, Bronx, NY 10462

来源：

Current Pain and Headache Reports | 2003年 / 7卷 / 1期

关键词：

Migraine; Valproate; Gabapentin; Antiepileptic Drug; Topiramate;

D O I：

10.1007/s11916-003-0012-6

中图分类号：

学科分类号：

摘要：

The mainstay of migraine treatment is pharmacotherapy. There have been numerous medications used to prevent migraine headaches, including β-blockers, calcium-channel blockers, anticonvulsants, and nonsteroidal anti-inflammatory drugs. Sodium valproate is the only antiepileptic drug approved by the Food and Drug Administration for migraine prevention. Newer antiepileptics, including gabapentin and topiramate, are being evaluated for their role in preventive therapy. The mechanism of action of antiepileptics is not fully understood, but they all share a common role in enhancing gamma-aminobutyric acid-mediated inhibition. This article reviews the role of anticonvulsants in preventive migraine therapy. Copyright © 2003 by Current Science Inc.

引用

页码：63 / 66

页数：3

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