The effect of past use of oral contraceptive on bone mineral density, bone biochemical markers and muscle strength in healthy pre and post menopausal women

被引：21

作者：

Allali F. ^{[1
,2
,3
]}

El Mansouri L. ^{[1
,2
]}

Abourazzak F.Z. ^{[1
,2
]}

Ichchou L. ^{[1
,2
]}

Khazzani H. ^{[1
,2
]}

Bennani L. ^{[1
,2
]}

Abouqal R. ^{[3
]}

Hajjaj-Hassouni N. ^{[1
,2
,3
]}

机构：

[1] Department of Rheumatology, El Ayachi University-Hospital, Sale

[2] LIRPOS: Laboratory of information and research on bone diseases, Faculty of Medicine and Pharmacy, Rabat

[3] Laboratory of Biostatistical, Clinical Research and Epidemiology (LBRCE), Faculty of Medicine and Pharmacy, Rabat

来源：

BMC Women's Health | / 9卷 / 1期

关键词：

Bone Mineral Density; Oral Contraceptive; Osteocalcin; Premenopausal Woman; Post Menopausal Woman;

D O I：

10.1186/1472-6874-9-31

中图分类号：

学科分类号：

摘要：

Background: during adulthood, most studies have reported that oral contraceptive (OC) pills had neutral, or possibly beneficial effect on bone health. We proposed this study of pre and post menopausal women assessing BMD, bone biochemical markers and physical performance among OC past users and comparable women who have never use Ocs. Methods: A cross-sectional study comparing the bone density, bone biochemical markers (osteocalcin, CTX) and three measures to assess physical performance: timed get-up-and-go test "TGUG", five-times-sit-to-stand test "5 TSTS" and 8-feet speed walk "8 FSW" of users and never users OC. We were recruited 210 women who used OC for at least 2 years with that of 200 nonusers was carried out in pre and postmenopausal women (24-86 years). Results: when analysing the whole population, BMD and biochemical markers values were similar for Ocs past users and control subjects. However when analysing the subgroup of premenopausal women, there was a statistically significant difference between users and never-users in osteocalcin (15,5 ± 7 ng/ml vs 21,6 ± 9 ng/ml; p = 0,003) and CTX (0,30 ± 0,1 ng/ml vs 0,41 ± 0,2 ng/ml; p = 0,025). This difference persisted after adjustment for age, BMI, age at menarche and number of pregnancies. In contrast, in post menopausal women, there was no difference in bone biochemical markers between OC users and the control. On the other hand OC past users had a significant greater performance than did the never users group. And when analysing the physical performance tests by quartile OC duration we found a significant negative association between the three tests and the use of OC more than 10 years. Conclusion: the funding show no evidence of a significant difference in BMD between Ocs users and never user control groups, a decrease in bone turn over in OC pre menopausal users and a greater physical performances in patients who used OC up than 10 years. © 2009 Allali et al; licensee BioMed Central Ltd.

引用

共 25 条

[1]

Kleerekoper M., Brienza R.S., Schultz L.R., Johnson C.C., Oral contraceptive use may protect against low bone mass. Henry Ford Hospital Osteoporosis Cooperative Research Group, Arch Intern Med, 151, pp. 1971-1976, (1991)

[2]

Gambacciani M., Monteleone P., Ciaponi M., Sacco A., Genazzani A.R., Effects of oral contraceptives on bone mineral density, Treat Endocrinol, 3, pp. 191-196, (2004)

[3]

Sultana S., Choudhury S., Choudhury S.A., Effect of combined oral contraceptives on bone mineral density in pre and postmenopausal women, Mymensingh Med J, 11, pp. 12-14, (2002)

[4]

Pasco J.A., Kotowicz M.A., Henry M.J., Panahi S., Seeman E., Nicholson G.C., Oral contraceptives and bone mineral density: A population-based study, Am J Obstet Gynecol, 182, pp. 265-269, (2000)

[5]

Reed S.D., Scholes D., LaCroix A.Z., Ichikawa L.E., Barlow W.E., Ott S.M., Longitudinal changes in bone density in relation to oral contraceptive use, Contraception, 68, pp. 177-182, (2003)

[6]

Wanichsetakul P., Kamudhamas A., Watanaruangkovit P., Siripakarn Y., Visutakul P., Bone mineral density at various anatomic bone sites in women receiving combined oral contraceptives and depot-medroxyprogesterone acetate for contraception, Contraception, 65, pp. 407-410, (2002)

[7]

Kuohung W., Borgatta L., Stubblefield P., Low-dose oral contraceptives and bone mineral density: an evidence-based analysis, Contraception, 61, pp. 77-82, (2000)

[8]

Prior J.C., Kirkland S.A., Joseph L., Kreiger N., Murray T.M., Hanley D.A., Adachi J.D., Vigna Y.M., Berger C., Blondeau L., Jackson S.A., Tenenhouse A., Oral contraceptive use and bone mineral density in premenopausal women: cross-sectional, population-based data from the Canadian Multicentre Osteoporosis Study, CMAJ, 165, pp. 1023-1029, (2001)

[9]

Laitinen K., Valimaki M., Keto P., Bone mineral density measured by dual-energy X-ray absorptiometry in healthy Finnish women, Calcif Tissue Int, 48, pp. 224-231, (1991)

[10]

Sarwar R., Niclos B.B., Rutherford O.M., Changes in muscle strength, relaxation rate and fatiguability during the human menstrual cycle, J Physiol, 15, pp. 267-272, (1996)

← 1 2 3 →