Regulation of NaCl transport in the renal collecting duct: Lessons from cultured cells

被引：31

作者：

Bens M. ^{[1
,2
]}

Chassin C. ^{[1
,2
]}

Vandewalle A. ^{[1
,2
]}

机构：

[1] INSERM, U773, Faculté de Médecine Xavier Bichat, 75870 Paris

[2] Université Paris 7, 75870 Paris, Denis Diderot, site Bichat

来源：

Pflügers Archiv | 2006年 / 453卷 / 2期

关键词：

Aldosterone; Arginine vasopressin; CFTR; Collecting duct; ENaC; Na[!sup]+[!/sup; K[!sup]+[!/sup]-ATPase; Renal tubule cell line;

D O I：

10.1007/s00424-006-0123-0

中图分类号：

学科分类号：

摘要：

The fine control of NaCl absorption regulated by hormones takes place in the distal nephron of the kidney. In collecting duct principal cells, the epithelial sodium channel (ENaC) mediates the apical entry of Na+, which is extruded by the basolateral Na+,K+-ATPase. Simian virus 40-transformed and "transimmortalized" collecting duct cell lines, derived from transgenic mice carrying a constitutive, conditionally, or tissue-specific promoter-regulated large T antigen, have been proven to be valuable tools for studying the mechanisms controlling the cell surface expression and trafficking of ENaC and Na+,K+-ATPase. These cell lines have made it possible to identify sets of aldosterone- and vasopressin-stimulated proteins, and have provided new insights into the concerted mechanism of action of serum- and glucocorticoid-inducible kinase 1 (Sgk1), ubiquitin ligase Nedd4-2 (neural precursor cell-expressed, developmentally down-regulated protein 4-2), and 14-3-3 regulatory proteins in modulating ENaC-mediated Na+ currents. Epidermal growth factor and induced leucine zipper protein have also been shown to repress and stimulate ENaC-dependent Na+ absorption, respectively, by activating or repressing the mitogen-activated protein kinase externally regulated kinase 1/2. Overall, these findings have provided evidence suggesting that multiple pathways are involved in regulating NaCl absorption in the distal nephron. © 2006 Springer-Verlag.

引用

页码：133 / 146

页数：13

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