Risk factors and immunological pathways for asthma and other allergic diseases in children: Background and methodology of a longitudinal study in a large urban center in Northeastern Brazil (Salvador-SCAALA study)

被引：90

作者：

Barreto M.L. ^{[1
]}

Cunha S.S. ^{[1
]}

Alcântara-Neves N. ^{[2
]}

Carvalho L.P. ^{[3
]}

Cruz Á.A. ^{[4
]}

Stein R.T. ^{[5
]}

Genser B. ^{[1
]}

Cooper P.J. ^{[6
]}

Rodrigues L.C. ^{[7
]}

机构：

[1] Instituto de Saúde Coletiva, Universiade Federal de Bahia, Salvador

[2] Instituto de Ciências da Saúde, Universidade Federal de Bahia, Salvador

[3] Centro de Pesquisas Gonçalo Moniz, FIOCRUZ, Salvador

[4] Centro de Enfermidades Respiratórias, Faculdade de Medicina, Universidade Federal de Bahia, Salvador

[5] Department of Pediatrics, School of Medicine, Pontifica Universidade Católica, Porto Alegre

[6] Instituto de Microbiologia, Universidad San Francisco de Quito, Quito

[7] Department of Epidemiology and Populations Health, London School of Hygiene and Tropical Medicine, London

来源：

BMC Pulmonary Medicine | / 6卷 / 1期

关键词：

Asthma; Atopic Eczema; Herpes Zoster; Allergic Disease; Skin Prick Test;

D O I：

10.1186/1471-2466-6-15

中图分类号：

学科分类号：

摘要：

Background: The prevalence of asthma and allergic diseases has increased in industrialised countries, and it is known that rates vary according whether the area is urban or rural and to socio-economic status. Surveys conducted in some urban settings in Latin America found high prevalence rates, only exceeded by the rates observed in industrialised English-speaking countries. It is likely that the marked changes in the environment, life style and living conditions in Latin America are responsible for these observations. The understanding of the epidemiological and immunological changes that underlie the increase in asthma and allergic diseases in Latin America aimed by SCAALA studies in Brazil and Ecuador will be crucial for the identification of novel preventive interventions. Methods/Design: The Salvador-SCAALA project described here is a longitudinal study involving children aged 4-11 years living in the city of Salvador, Northeastern Brazil. Data on asthma and allergic diseases (rhinitis and eczema) and potential risk factors will be collected in successive surveys using standardised questionnaire. This will be completed with data on dust collection (to dust mite and endotoxin), skin test to most common allergens, stool examinations to helminth and parasites, blood samples (to infection, total and specific IgE, and immunological makers), formaldehyde, physical inspection to diagnoses of eczema, and anthropometric measures. Data on earlier exposures when these children were 0-3 years old are available from a different project. Discussion: It is expected that knowledge generated may help identify public health interventions that may enable countries in LA to enjoy the benefits of a modern" lifestyle while avoiding - or minimising - increases in morbidity caused by asthma and allergies. © 2006 Barreto et al; licensee BioMed Central Ltd."

引用

共 31 条

[1]

Woolcock A.J., Peat J.K., Evidence for the increase in asthma worldwide, Ciba Found Symp, 206, pp. 122-134, (1997)

[2]

Upton M.N., McConnachie A., McSharry C., Hart C.L., Smith G.D., Gillis C.R., Watt G.C., Intergenerational 20 year trends in the prevalence of asthma and hay fever in adults: The Midspan family study surveys of parents and offspring, BMJ, 321, pp. 88-92, (2000)

[3]

Williams H.C., Is the prevalence of atopic dermatitis increasing?, Clin Exp Dermatol, 17, pp. 385-391, (1992)

[4]

von Mutius E., Environmental factors influencing the development and progression of pediatric asthma, J Allergy Clin Immunol, 109, (2002)

[5]

Strachan D.P., Hay fever, hygiene, and household size, BMJ, 299, pp. 1259-1260, (1989)

[6]

Matricardi P.M., Rosmini F., Riondino S., Fortini M., Ferrigno L., Rapicetta M., Bonini S., Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: Epidemiological study, BMJ, 320, 7232, pp. 412-417, (2000)

[7]

Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC, Lancet, 351, pp. 1225-1232, (1998)

[8]

Hoffman K., Centeno M.A., The lopsided continent: Inequality in Latin America, Annu Rev Sociol, 29, pp. 363-390, (2003)

[9]

Human Development Report 2003

[10]

Chatkin M.N., Menezes A.M., Victora C.G., Barros F.C., High prevalence of asthma in preschool children in Southern Brazil: A population-based study, Pediatr Pulmonol, 35, pp. 296-301, (2003)

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