Effects of Astragaloside IV on heart failure in rats

被引：50

作者：

Zhao Z. ^{[1
]}

Wang W. ^{[1
]}

Wang F. ^{[2
]}

Zhao K. ^{[3
]}

Han Y. ^{[1
]}

Xu W. ^{[1
]}

Tang L. ^{[1
]}

机构：

[1] State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research

[2] Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology

[3] Department of Pharmacy, Tianjin Medical College

来源：

Chinese Medicine | / 4卷 / 1期

关键词：

Left Ventricle; Model Group; Infarcted Area; Quinapril; Fractional Shorten;

D O I：

10.1186/1749-8546-4-6

中图分类号：

学科分类号：

摘要：

Background: Astragaloside IV (ASI) in Radix Astragali is believed to be the active component in treating heart failure. The present study aims to examine the effects of ASI on cardiovascular parameters in long-term heart failure in rats. Methods: Using echocardiographic and haemodynamic measurements, we studied the effects of ASI on congestive heart failure (CHF) induced by ligation of the left coronary artery in rats. Results: ASI (0.1, 0.3 and 1.0 mg/kg/day) attenuated the decline of fractional shortening (FS). The peak derivatives of the left ventricle (LV) pressure (dp/dt) in ASI-treated groups significantly increased. Both LV internal diameters in diastole (LVIDd) and in systole (LVIDs) decreased significantly after ASI treatment (0.3 and 1.0 mg/kg/day). ASI (1.0 mg/kg/day) attenuated the decrease of LV systolic pressure (LVSP). ASI treatment inhibited compensatory hypertrophy of myocardial cells and lowered the number of apoptotic myocytes. Conclusion: ASI improved cardiac functions as measured by cardiovascular parameters. © 2009 Zhao et al; licensee BioMed Central Ltd.

引用

共 30 条

[1]

Yuan G.P., Evaluation of efficacy of Astragalus injection in treatment of patients with chronic heart failure, Zhonguo Linchuang Yaolixue Yu Zhiliaoxue, 8, 6, pp. 710-711, (2003)

[2]

Zhai L.H., Wang M., Yue J.M., Ma Y.Z., The clinical study of Astragalus injection in treatment of patients with chronic heart failure, Shanghai Yiyao Zazhi, 11, pp. 10-12, (1995)

[3]

Zhu B.Q., Dai R.H., Gong Z.M., Study of the positive effect of astragala injection on heart, Shanghai Zhongyiyao Zazhi, 7, 1, pp. 47-48, (1987)

[4]

Li S.R., Hao J.F., Wang Y., Gao X.M., Hu L.M., Experimental research about the influence of Huangqi injection on hemodynamics in tars with acute heart failure, Tianjin Zhongyiyao, 20, 6, pp. 56-57, (2003)

[5]

Hong Y., Hui S.C., Chan T.Y., Hou J.Y., Study of the inhibitory effect of Hangqi injection on experimental cardiac hypertrophy in rats, Zhongchengyao, 24, 7, pp. 525-529, (2002)

[6]

Wu W.P., The experimental study of Astragaloside IV on cardiac effect, Zhongyaocai, 28, 7, pp. 591-592, (2005)

[7]

Sun C.W., Lu W.W., Effects of Astragalus saponins on experimental heart failure, Baiqiu'en Yikedaxue Xuebao, 20, 2, pp. 125-127, (1994)

[8]

Zheng P.L., Dai J.Y., Chen H., Fu W.P., Zhang C., Chen H.Z., Influence of astragaloside IV (ASIV) on systolic and diastolic function in dogs with acute heart failure, Zhongguo Yaolixue Tongbao, 21, 12, pp. 1534-1535, (2005)

[9]

Liu Y.X., Liu Z.P., Jiao J.J., Lou J.S., Effects of Astragaloside IV on myocardial dynamics and cardiac function with normal and depressant cardiac function in rats, Zhongcaoyao, 32, 4, pp. 332-334, (2001)

[10]

Liu Y.Y., Shen X.T., The comparison of cardiac effects of ASI, milrinone, and ouabain on heart failure in guinea pigs, Jichu Yixue Yu Linchuang, 21, 6, pp. 571-572, (2001)

← 1 2 3 →