Statins for stroke prevention

被引：7

作者：

Goldstein L.R. ^{[1
]}

机构：

[1] Duke Center for Cerebrovascular Disease, Stroke Policy Program, Duke University Medical Center, Durham, NC 27710

来源：

Current Atherosclerosis Reports | 2007年 / 9卷 / 4期

关键词：

Ischemic Stroke; Statin; Atorvastatin; Stroke Risk; Hemorrhagic Stroke;

D O I：

10.1007/s11883-007-0037-0

中图分类号：

学科分类号：

摘要：

Unlike coronary heart disease, epidemiologic studies find a weak and inconsistent relationship between cholesterol levels and overall stroke risk. There does, however, appear to be a positive relationship between total and low-density lipoprotein cholesterol levels and the risk of ischemic stroke, with an inverse relationship between cholesterol levels and hemorrhagic stroke. Treatment with statins is associated with the reduction in the risk of a first stroke in various populations of patients at increased risk of cardiovascular events. Treatment of patients with prior cerebrovascular disease is associated with a reduction in major cardiovascular events and, in a single study, with a reduction in fatal and nonfatal stroke in patients with prior stroke or transient ischemic attack and no known coronary heart disease. Whether the benefit of statins in reducing the risk of stroke is due to their potent lipid-lowering effects, pleiotropic effects, or a combination of the two cannot be determined based on data available from clinical trials. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：305 / 311

页数：6

共 47 条

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